dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016485
Uniprot Accession Q12102; CFT2_YEAST; D6VYB3; Q7LGW6;
Genbank Protein ID NP_013216.1;
Genbank Nucleotide ID NM_001182002.1;
Protein Name Cleavage factor two protein 2
Protein Synonyms/Alias 105 kDa protein associated with polyadenylation factor I;
Gene Name CFT2
Gene Synonyms/Alias YDH1;YLR115W;L2946;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
582LKDGAKTTSPVNEEDcurated25315811
583KDGAKTTSPVNEEDNcurated24961812; 25315811
601EEDGYNMSDPISKRScurated24961812; 25315811
Sequence
(Fasta)		MTYKYNCCDD GSGTTVGSVV RFDNVTLLID PGWNPSKVSY EQCIKYWEKV IPEIDVIILS 60
QPTIECLGAH SLLYYNFTSH FISRIQVYAT LPVINLGRVS TIDSYASAGV IGPYDTNKLD 120
LEDIEISFDH IVPLKYSQLV DLRSRYDGLT LLAYNAGVCP GGSIWCISTY SEKLVYAKRW 180
NHTRDNILNA ASILDATGKP LSTLMRPSAI ITTLDRFGSS QPFKKRSKIF KDTLKKGLSS 240
DGSVIIPVDM SGKFLDLFTQ VHELLFESTK INAHTQVPVL ILSYARGRTL TYAKSMLEWL 300
SPSLLKTWEN RNNTSPFEIG SRIKIIAPNE LSKYPGSKIC FVSEVGALIN EVIIKVGNSE 360
KTTLILTKPS FECASSLDKI LEIVEQDERN WKTFPEDGKS FLCDNYISID TIKEEPLSKE 420
ETEAFKVQLK EKKRDRNKKI LLVKRESKKL ANGNAIIDDT NGERAMRNQD ILVENVNGVP 480
PIDHIMGGDE DDDEEEENDN LLNLLKDNSE KSAAKKNTEV PVDIIIQPSA ASKHKMFPFN 540
PAKIKKDDYG TVVDFTMFLP DDSDNVNQNS RKRPLKDGAK TTSPVNEEDN KNEEEDGYNM 600
SDPISKRSKH RASRYSGFSG TGEAENFDNL DYLKIDKTLS KRTISTVNVQ LKCSVVILNL 660
QSLVDQRSAS IIWPSLKSRK IVLSAPKQIQ NEEITAKLIK KNIEVVNMPL NKIVEFSTTI 720
KTLDISIDSN LDNLLKWQRI SDSYTVATVV GRLVKESLPQ VNNHQKTASR SKLVLKPLHG 780
SSRSHKTGAL SIGDVRLAQL KKLLTEKNYI AEFKGEGTLV INEKVAVRKI NDAETIIDGT 840
PSELFDTVKK LVTDMLAKI
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR022712--Beta_Casp
IPR027075--CPSF2
IPR025069--Cpsf2_C
IPR001279--Metallo-B-lactamas
PROSITE
Pfam

PF13299--CPSF100_C
PF16661--Lactamase_B_6
Gene Ontology

GO:0005847--C:mRNA cleavage and polyadenylation specificity factor complex
GO:0005849--C:mRNA cleavage factor complex
GO:0003723--F:RNA binding
GO:0006378--P:mRNA polyadenylation
GO:0098789--P:pre-mRNA cleavage required for polyadenylation