dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0016480 | ||||||||
| Uniprot Accession | Q12093; MTU1_YEAST; D6VRW0; Q6IUF4; | ||||||||
| Genbank Protein ID | NP_010251.1; | ||||||||
| Genbank Nucleotide ID | NM_001180092.1; | ||||||||
| Protein Name | Mitochondrial tRNA-specific 2-thiouridylase 1 | ||||||||
| Protein Synonyms/Alias | Mitochondrial translation optimization protein 2;Synthetic lethal with MSS4 3; | ||||||||
| Gene Name | SLM3 | ||||||||
| Gene Synonyms/Alias | MTO2;MTU1;YDL033C;D2761; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MLARYLNLIG RRSASPYRPQ RLPAKFDNVI VAMSSGVDSS VAAALFAGEF PNTRGVYMQN 60 WSESQSLDDP GKEPCYERDW RDVNRVAKHL NIRVDKVNFE QDYWIDVFEP MLRGYSEGST 120 PNPDIGCNKF VKFGKLREWL DEKYGTGNYW LVTGHYARVM QEMNGKGLFH LLRSIYRPKD 180 QSYYLSQINS TVLSSLLLPI GHLTKPEVRD LAKYAGLPTA EKPDSQGICF VNNSQHGKFK 240 NFLKHYLPSS PGDIITVDPQ SGAKTTWGRH DGLWSYTIGQ KVGISMPQAD PNYQGTWFVS 300 EKLRDTNEIL IVRGRDNPAL YSDTMRIENF SSLGPREDTI NAFQNTGALT LQFRSLQVPV 360 QIKSCKLNRS ADNLDITIHL ASKQRAITPG QSCCLYIDDR VLGSGPISHV NNNDTHA 418 |
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| Keyword | KW-0067--ATP-binding |
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| Interpro | IPR023382--Adenine_a_hdrlase_dom |
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| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005739--C:mitochondrion |