dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016370
Uniprot Accession Q10489; ODPA_SCHPO;
Genbank Protein ID NP_594892.1;
Genbank Nucleotide ID NM_001020321.2;
Protein Name Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
Protein Synonyms/Alias
Gene Name pda1
Gene Synonyms/Alias SPAC26F1.03;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
6--MFRTCTKIGTVPKdbPTM 3.0;UniProt18257517; 16381945; 23193290
306MEFVTYRYGGHSMSDdbPTM 3.0;UniProt18257517; 16381945; 23193290
310TYRYGGHSMSDPGTTdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
312RYGGHSMSDPGTTYRdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)		MFRTCTKIGT VPKVLVNQKG LIDGLRRVTT DATTSRANPA HVPEEHDKPF PVKLDDSVFE 60
GYKIDVPSTE IEVTKGELLG LYEKMVTIRR LELACDALYK AKKIRGFCHL SIGQEAVAAG 120
IEGAITLDDS IITSYRCHGF AYTRGLSIRS IIGELMGRQC GASKGKGGSM HIFAKNFYGG 180
NGIVGAQIPL GAGIGFAQKY LEKPTTTFAL YGDGASNQGQ AFEAFNMAKL WGLPVIFACE 240
NNKYGMGTSA ERSSAMTEFY KRGQYIPGLL VNGMDVLAVL QASKFAKKYT VENSQPLLME 300
FVTYRYGGHS MSDPGTTYRS REEVQKVRAA RDPIEGLKKH IMEWGVANAN ELKNIEKRIR 360
GMVDEEVRIA EESPFPDPIE ESLFSDVYVA GTEPAYARGR NSLEYHQYK
Keyword

KW-0181--Complete proteome
KW-0324--Glycolysis
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0670--Pyruvate
KW-1185--Reference proteome
KW-0786--Thiamine pyrophosphate
KW-0809--Transit peptide
Interpro

IPR001017--DH_E1
IPR017597--Pyrv_DH_E1_asu_subgrp-y
IPR029061--THDP-binding
PROSITE
Pfam

PF00676--E1_dh
Gene Ontology

GO:0005967--C:mitochondrial pyruvate dehydrogenase complex
GO:0005739--C:mitochondrion
GO:0004739--F:pyruvate dehydrogenase (acetyl-transferring) activity
GO:0006086--P:acetyl-CoA biosynthetic process from pyruvate
GO:0006096--P:glycolytic process