| Tag |
Content |
| dbPAF ID |
dbPAF-0016356 |
| Uniprot Accession |
Q10434; CAPZA_SCHPO;
|
| Genbank Protein ID |
NP_594639.1;
|
| Genbank Nucleotide ID |
NM_001020067.2;
|
| Protein Name |
F-actin-capping protein subunit alpha |
| Protein Synonyms/Alias |
|
| Gene Name |
acp1 |
| Gene Synonyms/Alias |
SPAC12B10.07; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction.Functional Description
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MEKEAIYKLI RESPPGEVNQ VVHDIRDIGL SDEEAIHEQL KLYHEDYNSS VSISDDEKVI 60
ISADNRLEGN RYYDQVLQKS FTINYETMEA ENVEDYTEAI KIPDEIVKQI KKVASDHYLS 120
DVTFGIIKKS DEVESFTIVL VSSKYNPKNY WNGSWRCICN YNVSEKKLEG RSHIRVHYYE 180
DGNVWLDASR PISATVEETS KLYEVLAQVE NGIQQSFNVE LSSLNDKKFK ELRRQLPVTR 240
QKINWENVSG IRMRNT
257Fasta Sequence
>Q10434|acp1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MEKEAIYKLIRESPPGEVNQVVHDIRDIGLSDEEAIHEQLKLYHEDYNSSVSISDDEKVIISADNRLEGNRYYDQVLQKSFTINYETMEAENVEDYTEAIKIPDEIVKQIKKVASDHYLSDVTFGIIKKSDEVESFTIVLVSSKYNPKNYWNGSWRCICNYNVSEKKLEGRSHIRVHYYEDGNVWLDASRPISATVEETSKLYEVLAQVENGIQQSFNVELSSLNDKKFKELRRQLPVTRQKINWENVSGIRMRNT
|
| Keyword |
KW-0117--Actin capping
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR002189--CapZ_alpha
IPR017865--F-actin_cap_asu_CS
|
| PROSITE |
PS00748--F_ACTIN_CAPPING_A_1
PS00749--F_ACTIN_CAPPING_A_2
|
| Pfam |
PF01267--F-actin_cap_A
|
| Gene Ontology |
GO:0030479--C:actin cortical patch
GO:0005884--C:actin filament
GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0008290--C:F-actin capping protein complex
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0051016--P:barbed-end actin filament capping
GO:0034613--P:cellular protein localization
GO:0000281--P:mitotic cytokinesis
GO:0030835--P:negative regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
|
