| Tag |
Content |
| dbPAF ID |
dbPAF-0016348 |
| Uniprot Accession |
Q10407; MKH1_SCHPO;
|
| Genbank Protein ID |
NP_593005.1;
|
| Genbank Nucleotide ID |
NM_001018404.2;
|
| Protein Name |
MAP kinase kinase kinase mkh1 |
| Protein Synonyms/Alias |
|
| Gene Name |
mkh1 |
| Gene Synonyms/Alias |
SPAC1F3.02c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation.Functional Description
May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAADIGSQSS GSLEERFEQS LHLQNVDKQD WSLNSVLQFL KLYKFNKEWE DVFIKSRIEM 60
DLFINLADQS KAEEFAFKNK LSKESAIQLS SCIRKTLLAP SSTRVPSKNS SYETLTYSAK 120
DSSDDVFTET NSGFRSSNQN SSLKSFQSVP DSNVNVFGGF GGSVVDNNEL LSTGKNSHQT 180
TSLNLEGSPI NLHAYKGTVT SIINDDSRNI NKKTLSKQPV SEHKEKQTSF LRRFRVPGFS 240
RDKDKTKDCP SSNSNPFHLA SSNVKTLDAS LDQGEWVPRI HRLESQIGLI SKKKSFVLAT 300
MDDMKFTVVD ITNVQNATQL RKLIAKSMYL DISIDQFDLF LTEVGGAQYI EILDDRKLDI 360
ARLYSDEFGT IKFFVKPSQN EESGMDSDTY LSFGTKSSST YKADDDSIYH RKEDFKKQPS 420
YPVLTSDFEI TDAGPNLSLS GHQPDNKYYK GFSSAPNLAV VPELPSRRFR GFEKIRGAKG 480
EMATKILDAT EAQSEKNKFT VCRPHKKVTL KMPLNSGSSA PQSPSSNTSA SVLTRNFVAH 540
RDPPPPPTET SSLRRKNTLT RRPSIRHARS SPYIDTGHNE ASKFSHTSFD PKASSKSSNS 600
LKESVEALSE IPFEDAPALD ESDLSGDPFW AIQPKQSSSQ VPKENHHNIQ SKLSINTEAA 660
TDLKANELSS PKTPEYCRGD DRSISLSPLS YRLRKSKHIR ESPPSSKVIN SGNWEVRPSA 720
DDLYEDVDRF FPRYDLDKVL VVDQSRMVSS PSKVSIRPKM KSVRLLAREA SEARKEIRHN 780
ARRNKSGNLL RRSSTKLWGS RIVELKPDTT ITSGSVVSQN ATFKWMKGEL IGNGTYGKVF 840
LAMNINTGEL IAVKQVEIPQ TINGRHDQLR KDIVDSINAE ISMIADLDHL NIVQYLGFEK 900
TETDISIFLE YVSGGSIGRC LRNYGPFEEQ LVRFVSRQVL YGLSYLHSKG IIHRDLKADN 960
LLIDFDGVCK ISDFGISKHS DNVYDNDANL SMQGSIFWMA PEVIHNDHQG YSAKVDVWSL 1020
GCVVLEMLAG RRPWSTDEAI QAMFKLGTEK KAPPIPSELV SQVSPEAIQF LNACFTVNAD 1080
VRPTAEELLN HPFMKCDEEF NFKDTNLYDM LCKRKS
1117Fasta Sequence
>Q10407|mkh1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MAADIGSQSSGSLEERFEQSLHLQNVDKQDWSLNSVLQFLKLYKFNKEWEDVFIKSRIEMDLFINLADQSKAEEFAFKNKLSKESAIQLSSCIRKTLLAPSSTRVPSKNSSYETLTYSAKDSSDDVFTETNSGFRSSNQNSSLKSFQSVPDSNVNVFGGFGGSVVDNNELLSTGKNSHQTTSLNLEGSPINLHAYKGTVTSIINDDSRNINKKTLSKQPVSEHKEKQTSFLRRFRVPGFSRDKDKTKDCPSSNSNPFHLASSNVKTLDASLDQGEWVPRIHRLESQIGLISKKKSFVLATMDDMKFTVVDITNVQNATQLRKLIAKSMYLDISIDQFDLFLTEVGGAQYIEILDDRKLDIARLYSDEFGTIKFFVKPSQNEESGMDSDTYLSFGTKSSSTYKADDDSIYHRKEDFKKQPSYPVLTSDFEITDAGPNLSLSGHQPDNKYYKGFSSAPNLAVVPELPSRRFRGFEKIRGAKGEMATKILDATEAQSEKNKFTVCRPHKKVTLKMPLNSGSSAPQSPSSNTSASVLTRNFVAHRDPPPPPTETSSLRRKNTLTRRPSIRHARSSPYIDTGHNEASKFSHTSFDPKASSKSSNSLKESVEALSEIPFEDAPALDESDLSGDPFWAIQPKQSSSQVPKENHHNIQSKLSINTEAATDLKANELSSPKTPEYCRGDDRSISLSPLSYRLRKSKHIRESPPSSKVINSGNWEVRPSADDLYEDVDRFFPRYDLDKVLVVDQSRMVSSPSKVSIRPKMKSVRLLAREASEARKEIRHNARRNKSGNLLRRSSTKLWGSRIVELKPDTTITSGSVVSQNATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMKCDEEFNFKDTNLYDMLCKRKS
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001660--SAM
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0032153--C:cell division site
GO:0030428--C:cell septum
GO:0051286--C:cell tip
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0008349--F:MAP kinase kinase kinase kinase activity
GO:0000186--P:activation of MAPKK activity
GO:0000185--P:activation of MAPKKK activity
GO:0006883--P:cellular sodium ion homeostasis
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0071852--P:fungal-type cell wall organization or biogenesis
GO:0000165--P:MAPK cascade
GO:0000281--P:mitotic cytokinesis
GO:0042981--P:regulation of apoptotic process
GO:0008360--P:regulation of cell shape
GO:0007346--P:regulation of mitotic cell cycle
GO:0031098--P:stress-activated protein kinase signaling cascade
|
