| Tag |
Content |
| dbPAF ID |
dbPAF-0016327 |
| Uniprot Accession |
Q10283; HMDH_SCHPO; O74425;
|
| Genbank Protein ID |
NP_588235.1;
|
| Genbank Nucleotide ID |
NM_001023225.2;
|
| Protein Name |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Protein Synonyms/Alias |
|
| Gene Name |
hmg1 |
| Gene Synonyms/Alias |
its12;SPCC162.09c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.Functional Description
Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MIYKLAARYP IQVIAIVGIL VSMAYFSFLE ALTQEDFPVL IRALKRFGIL DGFPNTRLPN 60
EMILKLSSVQ GEDASVWEQI PAAELGGEGF VDFDITQWYY PANAKVDVAQ LVEPYRNDCI 120
FHDASGACHF FFKEVGNWTV SSIALPSNLA NPPIDYFLDS SSTVIQRILP AIREHGISWS 180
WLLQLIARTW MNTLKIASQA SKTELLIVGT AYACMLISIV SLYLKMRRLG SKFWLFFSVL 240
LSTLFSVQFA MTLVRASGVR ISLVSLIESL PFLINVVALD KAAELTRQVI TRCSVSDSHS 300
PMHEDIAKAC RNAAPPILRH FSFGIVVLAI FSYCNFGIKQ FFLFAAVMIY DLLLLFSFFV 360
AILTLKLEMR RYNAKDDVRK VLIEEGLSES TARHVADGND SSATTSAGSR YFKVRYGTKI 420
ILFIFIAFNL FELCSIPFKH YAATSAAAAR LIPLVRSQYP DFKSQRLLDD GVFDDVLSAI 480
SSMSNIESPS VRLLPAVFYG AELSSTSFLS TIHSFINNWS HYISASFLSK WIVCALSLSI 540
AVNVFLLNAA RLNSIKEEPE KKVVEKVVEV VKYIPSSNSS SIDDIQKDEI AQESVVRSLE 600
ECITLYNNGQ ISTLNDEEVV QLTLAKKIPL YALERVLKDV TRAVVIRRTV VSRSSRTKTL 660
ESSNCPVYHY DYSRVLNACC ENVIGYMPLP LGVAGPLIID GKPFYIPMAT TEGALVASTM 720
RGCKAINAGG GAVTVLTRDQ MSRGPCVAFP NLTRAGRAKI WLDSPEGQEV MKKAFNSTSR 780
FARLQHIKTA LAGTRLFIRF CTSTGDAMGM NMISKGVEHA LVVMSNDAGF DDMQVISVSG 840
NYCTDKKPAA INWIDGRGKS VIAEAIIPGD AVKSVLKTTV EDLVKLNVDK NLIGSAMAGS 900
VGGFNAHAAN IVTAVYLATG QDPAQNVESS NCITLMDNVD GNLQLSVSMP SIEVGTIGGG 960
TVLEPQGAML DLLGVRGAHM TSPGDNSRQL ARVVAAAVMA GELSLCSALA SGHLVKSHIG 1020
LNRSALNTPA MDSSAKKPAT DALKSVNSRV PGR
1054Fasta Sequence
>Q10283|hmg1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MIYKLAARYPIQVIAIVGILVSMAYFSFLEALTQEDFPVLIRALKRFGILDGFPNTRLPNEMILKLSSVQGEDASVWEQIPAAELGGEGFVDFDITQWYYPANAKVDVAQLVEPYRNDCIFHDASGACHFFFKEVGNWTVSSIALPSNLANPPIDYFLDSSSTVIQRILPAIREHGISWSWLLQLIARTWMNTLKIASQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVLLSTLFSVQFAMTLVRASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHSPMHEDIAKACRNAAPPILRHFSFGIVVLAIFSYCNFGIKQFFLFAAVMIYDLLLLFSFFVAILTLKLEMRRYNAKDDVRKVLIEEGLSESTARHVADGNDSSATTSAGSRYFKVRYGTKIILFIFIAFNLFELCSIPFKHYAATSAAAARLIPLVRSQYPDFKSQRLLDDGVFDDVLSAISSMSNIESPSVRLLPAVFYGAELSSTSFLSTIHSFINNWSHYISASFLSKWIVCALSLSIAVNVFLLNAARLNSIKEEPEKKVVEKVVEVVKYIPSSNSSSIDDIQKDEIAQESVVRSLEECITLYNNGQISTLNDEEVVQLTLAKKIPLYALERVLKDVTRAVVIRRTVVSRSSRTKTLESSNCPVYHYDYSRVLNACCENVIGYMPLPLGVAGPLIIDGKPFYIPMATTEGALVASTMRGCKAINAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLDSPEGQEVMKKAFNSTSRFARLQHIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSGNYCTDKKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGSVGGFNAHAANIVTAVYLATGQDPAQNVESSNCITLMDNVDGNLQLSVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIGLNRSALNTPAMDSSAKKPATDALKSVNSRVPGR
|
| Keyword |
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR002202--HMG_CoA_Rdtase
IPR023074--HMG_CoA_Rdtase_cat
IPR023076--HMG_CoA_Rdtase_CS
IPR004554--HMG_CoA_Rdtase_eu_arc
IPR023282--HMG_CoA_Rdtase_N
IPR009023--HMG_CoA_Rdtase_NAD(P)-bd_dom
IPR009029--HMG_CoA_Rdtase_sub-bd_dom
IPR000731--SSD
|
| PROSITE |
PS00066--HMG_COA_REDUCTASE_1
PS00318--HMG_COA_REDUCTASE_2
PS50065--HMG_COA_REDUCTASE_4
PS50156--SSD
|
| Pfam |
PF00368--HMG-CoA_red
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0031965--C:nuclear membrane
GO:0042175--C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005778--C:peroxisomal membrane
GO:0004420--F:hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282--F:hydroxymethylglutaryl-CoA reductase activity
GO:0050661--F:NADP binding
GO:0015936--P:coenzyme A metabolic process
GO:0006696--P:ergosterol biosynthetic process
GO:0010142--P:farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287--P:isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299--P:isoprenoid biosynthetic process
|
