| Tag |
Content |
| dbPAF ID |
dbPAF-0010628 |
| Uniprot Accession |
P45381; ACY2_HUMAN;
|
| Genbank Protein ID |
NP_000040.1; NP_001121557.1; XP_006721590.1;
|
| Genbank Nucleotide ID |
NM_000049.2; NM_001128085.1; XM_006721527.2;
|
| Protein Name |
Aspartoacylase |
| Protein Synonyms/Alias |
Aminoacylase-2;ACY-2; |
| Gene Name |
ASPA |
| Gene Synonyms/Alias |
ACY2;ASP; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.Functional Description
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MTSCHIAEEH IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP FITNPRAVKK 60
CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF GPKDSEDSYD IIFDLHNTTS 120
NMGCTLILED SRNNFLIQMF HYIKTSLAPL PCYVYLIEHP SLKYATTRSI AKYPVGIEVG 180
PQPQGVLRAD ILDQMRKMIK HALDFIHHFN EGKEFPPCAI EVYKIIEKVD YPRDENGEIA 240
AIIHPNLQDQ DWKPLHPGDP MFLTLDGKTI PLGGDCTVYP VFVNEAAYYE KKEAFAKTTK 300
LTLNAKSIRC CLH
314Fasta Sequence
>P45381|ASPA|Homo sapiens(Human)
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCLH
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-1026--Leukodystrophy
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
|
| Interpro |
IPR016708--Aspartoacylase
IPR007036--Aste_AspA
|
| PROSITE |
|
| Pfam |
PF04952--AstE_AspA
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0004046--F:aminoacylase activity
GO:0019807--F:aspartoacylase activity
GO:0016788--F:hydrolase activity, acting on ester bonds
GO:0046872--F:metal ion binding
GO:0006533--P:aspartate catabolic process
GO:0008652--P:cellular amino acid biosynthetic process
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0022010--P:central nervous system myelination
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0044281--P:small molecule metabolic process
|
