| Tag |
Content |
| dbPAF ID |
dbPAF-0010230 |
| Uniprot Accession |
P41159; LEP_HUMAN; O15158; Q56A88;
|
| Genbank Protein ID |
NP_000221.1; XP_005250397.1;
|
| Genbank Nucleotide ID |
NM_000230.2; XM_005250340.3;
|
| Protein Name |
Leptin |
| Protein Synonyms/Alias |
Obese protein;Obesity factor; |
| Gene Name |
LEP |
| Gene Synonyms/Alias |
OB;OBS; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.Functional Description
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 48 | RINDISHTQSVSSKQ | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL 60
DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP 120
WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
168Fasta Sequence
>P41159|LEP|Homo sapiens(Human)
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0219--Diabetes mellitus
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0550--Obesity
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR009079--4_helix_cytokine-like_core
IPR012351--4_helix_cytokine_core
IPR000065--Leptin
|
| PROSITE |
|
| Pfam |
PF02024--Leptin
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0060612--P:adipose tissue development
GO:0008343--P:adult feeding behavior
GO:0008206--P:bile acid metabolic process
GO:0035630--P:bone mineralization involved in bone maturation
GO:0003300--P:cardiac muscle hypertrophy
GO:0071298--P:cellular response to L-ascorbic acid
GO:0071300--P:cellular response to retinoic acid
GO:0021954--P:central nervous system neuron development
GO:0008203--P:cholesterol metabolic process
GO:0007623--P:circadian rhythm
GO:0042755--P:eating behavior
GO:0006112--P:energy reserve metabolic process
GO:0006635--P:fatty acid beta-oxidation
GO:0007565--P:female pregnancy
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0006114--P:glycerol biosynthetic process
GO:0042445--P:hormone metabolic process
GO:0030073--P:insulin secretion
GO:0033210--P:leptin-mediated signaling pathway
GO:0050901--P:leukocyte tethering or rolling
GO:0043066--P:negative regulation of apoptotic process
GO:0032099--P:negative regulation of appetite
GO:0061037--P:negative regulation of cartilage development
GO:0070093--P:negative regulation of glucagon secretion
GO:2000486--P:negative regulation of glutamine transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045906--P:negative regulation of vasoconstriction
GO:0001542--P:ovulation from ovarian follicle
GO:0001890--P:placenta development
GO:0008284--P:positive regulation of cell proliferation
GO:0001819--P:positive regulation of cytokine production
GO:0048639--P:positive regulation of developmental growth
GO:0046881--P:positive regulation of follicle-stimulating hormone secretion
GO:2000491--P:positive regulation of hepatic stellate cell activation
GO:0046628--P:positive regulation of insulin receptor signaling pathway
GO:0043270--P:positive regulation of ion transport
GO:0033686--P:positive regulation of luteinizing hormone secretion
GO:0043410--P:positive regulation of MAPK cascade
GO:0045639--P:positive regulation of myeloid cell differentiation
GO:0035360--P:positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:2000366--P:positive regulation of STAT protein import into nucleus
GO:0042517--P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0008217--P:regulation of blood pressure
GO:0045598--P:regulation of fat cell differentiation
GO:0006111--P:regulation of gluconeogenesis
GO:0050796--P:regulation of insulin secretion
GO:0030300--P:regulation of intestinal cholesterol absorption
GO:0060587--P:regulation of lipoprotein lipid oxidation
GO:0050810--P:regulation of steroid biosynthetic process
GO:0002021--P:response to dietary excess
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0033197--P:response to vitamin E
GO:0007260--P:tyrosine phosphorylation of STAT protein
|
