dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0008881
Uniprot Accession P35318; ADML_HUMAN; B2R793; D3DQV3; Q6FGW2;
Genbank Protein ID NP_001115.1;
Genbank Nucleotide ID NM_001124.2;
Protein Name ADM
Protein Synonyms/Alias
Gene Name ADM
Gene Synonyms/Alias AM;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
49GKRELRMSSSYPTGLPhosphoSitePlus22135298
50KRELRMSSSYPTGLAPhosphoSitePlus22135298
51RELRMSSSYPTGLADPhosphoSitePlus22135298
52ELRMSSSYPTGLADVPhosphoSitePlus22135298
54RMSSSYPTGLADVKAPhosphoSitePlus22135298
125QKLAHQIYQFTDKDKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 19060867; 22135298; 22817900
128AHQIYQFTDKDKDNVPhosphoSitePlus22135298
146SKISPQGYGRRRRRSPhosphoSitePlus22135298
153YGRRRRRSLPEAGPGcurated20873877
Sequence
(Fasta)		MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK 60
AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL 120
AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS 180
APHFL 186
Keyword

KW-0002--3D-structure
KW-0027--Amidation
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0372--Hormone
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR001710--Adrenomedullin
IPR021116--Calcitonin/adrenomedullin
PROSITE
Pfam

PF00214--Calc_CGRP_IAPP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005102--F:receptor binding
GO:0007568--P:aging
GO:0008209--P:androgen metabolic process
GO:0019731--P:antibacterial humoral response
GO:0008015--P:blood circulation
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0006171--P:cAMP biosynthetic process
GO:0019933--P:cAMP-mediated signaling
GO:0007267--P:cell-cell signaling
GO:0050829--P:defense response to Gram-negative bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0048589--P:developmental growth
GO:0007565--P:female pregnancy
GO:0002031--P:G-protein coupled receptor internalization
GO:0007507--P:heart development
GO:0046879--P:hormone secretion
GO:0008285--P:negative regulation of cell proliferation
GO:0043116--P:negative regulation of vascular permeability
GO:0045906--P:negative regulation of vasoconstriction
GO:0001843--P:neural tube closure
GO:0031102--P:neuron projection regeneration
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0031100--P:organ regeneration
GO:0045766--P:positive regulation of angiogenesis
GO:0043065--P:positive regulation of apoptotic process
GO:0030819--P:positive regulation of cAMP biosynthetic process
GO:0008284--P:positive regulation of cell proliferation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010460--P:positive regulation of heart rate
GO:2001214--P:positive regulation of vasculogenesis
GO:0045909--P:positive regulation of vasodilation
GO:0006701--P:progesterone biosynthetic process
GO:0031623--P:receptor internalization
GO:0002026--P:regulation of the force of heart contraction
GO:0009409--P:response to cold
GO:0051384--P:response to glucocorticoid
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032496--P:response to lipopolysaccharide
GO:0042594--P:response to starvation
GO:0009611--P:response to wounding
GO:0007165--P:signal transduction
GO:0060712--P:spongiotrophoblast layer development
GO:0097084--P:vascular smooth muscle cell development
GO:0001570--P:vasculogenesis