dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0007575
Uniprot Accession P26651; TTP_HUMAN; B2RA54;
Genbank Protein ID NP_003398.2;
Genbank Nucleotide ID NM_003407.3;
Protein Name Tristetraprolin
Protein Synonyms/Alias
Gene Name ZFP36
Gene Synonyms/Alias G0S24;RNF162A;TIS11A;TTP;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
Phosphorylation Sites
 dbPAF PTMs: 50 (View all)
PositionPeptidesSourceReferences ( PMIDs )
12AIYESLLSLSPDVPVdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
21SPDVPVPSDHGGTESdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
41SSGPWSLSPSDSSPSdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
43GPWSLSPSDSSPSGVdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
46SLSPSDSSPSGVTSRdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
48SPSDSSPSGVTSRLPdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
52SSPSGVTSRLPGRSTdbPTM 3.0;HPRD 914688255; 16381945; 23193290; 18988627
60RLPGRSTSLVEGRSCdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated15014438; 16381945; 23193290; 14688255; 18988627; 22135298;
66TSLVEGRSCGWVPPPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated16262601; 16381945; 23193290; 20221403; 22135298; 22817900
88PRLGPELSPSPTSPTdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated16262601; 16381945; 23193290; 20393185; 22135298; 23090842;
90LGPELSPSPTSPTATdbPTM 3.0;PhosphoSitePlus;curated16262601; 20393185; 16381945; 23193290; 22135298; 23090842;
92PELSPSPTSPTATSTdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 16262601; 21081558; 22135298;
93ELSPSPTSPTATSTTdbPTM 3.0;PhosphoSitePlus;curated16262601; 20221403; 16381945; 23193290; 22135298; 23917254;
95SPSPTSPTATSTTPSdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 23090842; 22817900
97SPTSPTATSTTPSRYcurated23090842
98PTSPTATSTTPSRYKcurated19369195
99TSPTATSTTPSRYKTPhosphoSitePlus22135298
106TTPSRYKTELCRTFSdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
111YKTELCRTFSESGRCdbPTM 3.0;PhosphoSitePlus;curated16262601; 16381945; 23193290; 22135298; 22817900
113TELCRTFSESGRCRYPhosphoSitePlus;curated22135298; 22817900
Sequence
(Fasta)		MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS 60
LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY 120
GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV 180
LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL 240
ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE 300
AGVFAPPQPV AAPRRLPIFN RISVSE 327
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000571--Znf_CCCH
PROSITE

PS50103--ZF_C3H1
Pfam

PF00642--zf-CCCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0071889--F:14-3-3 protein binding
GO:0017091--F:AU-rich element binding
GO:0019957--F:C-C chemokine binding
GO:0003677--F:DNA binding
GO:0019899--F:enzyme binding
GO:0046872--F:metal ion binding
GO:0035925--F:mRNA 3'-UTR AU-rich region binding
GO:0003729--F:mRNA binding
GO:0044822--F:poly(A) RNA binding
GO:0019901--F:protein kinase binding
GO:0003727--F:single-stranded RNA binding
GO:0070935--P:3'-UTR-mediated mRNA stabilization
GO:0010467--P:gene expression
GO:0006402--P:mRNA catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035278--P:negative regulation of translation involved in gene silencing by miRNA
GO:0000288--P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153--P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0060213--P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0043488--P:regulation of mRNA stability
GO:0032680--P:regulation of tumor necrosis factor production
GO:0042594--P:response to starvation