dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006982
Uniprot Accession P22303; ACES_HUMAN; A4D2E2; B7ZKZ0; D6W5X7; Q16169; Q29S23; Q2M324; Q504V3; Q53F46; Q86TM9; Q86YX9; Q9BXP7;
Genbank Protein ID NP_000656.1; NP_001269378.1; NP_001289550.1; NP_001289551.1; NP_056646.1; XP_006716058.1; XP_011514529.1; XP_011514530.1; XP_011514531.1;
Genbank Nucleotide ID NM_000665.4; NM_001282449.1; NM_001302621.1; NM_001302622.1; NM_015831.2; XM_006715995.2; XM_011516227.1; XM_011516228.1; XM_011516229.1;
Protein Name Acetylcholinesterase
Protein Synonyms/Alias
Gene Name ACHE
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
164GASSLDVYDGRFLVQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus7836436; 16381945; 23193290; 18988627; 22135298
517YWANFARTGDPNEPRPhosphoSitePlus22135298
Sequence
(Fasta)		MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV 60
SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN 120
RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM 180
NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV 240
GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL 300
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG 360
VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE 420
DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY 480
EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ 540
YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 600
QFDHYSKQDR CSDL 615
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0095--Blood group antigen
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0531--Neurotransmitter degradation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0719--Serine esterase
KW-0732--Signal
KW-0770--Synapse
Interpro

IPR029058--AB_hydrolase
IPR014788--AChE_tetra
IPR002018--CarbesteraseB
IPR019826--Carboxylesterase_B_AS
IPR019819--Carboxylesterase_B_CS
IPR000997--Cholinesterase
PROSITE

PS00122--CARBOXYLESTERASE_B_1
PS00941--CARBOXYLESTERASE_B_2
Pfam

PF08674--AChE_tetra
PF00135--COesterase
Gene Ontology

GO:0031225--C:anchored component of membrane
GO:0005605--C:basal lamina
GO:0030054--C:cell junction
GO:0009986--C:cell surface
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0043083--C:synaptic cleft
GO:0042166--F:acetylcholine binding
GO:0003990--F:acetylcholinesterase activity
GO:0001540--F:beta-amyloid binding
GO:0004104--F:cholinesterase activity
GO:0005518--F:collagen binding
GO:0016787--F:hydrolase activity
GO:0043236--F:laminin binding
GO:0042803--F:protein homodimerization activity
GO:0017171--F:serine hydrolase activity
GO:0006581--P:acetylcholine catabolic process
GO:0001507--P:acetylcholine catabolic process in synaptic cleft
GO:0042982--P:amyloid precursor protein metabolic process
GO:0007155--P:cell adhesion
GO:0008283--P:cell proliferation
GO:0006260--P:DNA replication
GO:0046474--P:glycerophospholipid biosynthetic process
GO:0007517--P:muscle organ development
GO:0032223--P:negative regulation of synaptic transmission, cholinergic
GO:0007399--P:nervous system development
GO:0042136--P:neurotransmitter biosynthetic process
GO:0045212--P:neurotransmitter receptor biosynthetic process
GO:0002076--P:osteoblast development
GO:0006656--P:phosphatidylcholine biosynthetic process
GO:0006644--P:phospholipid metabolic process
GO:0050714--P:positive regulation of protein secretion
GO:0051262--P:protein tetramerization
GO:0031623--P:receptor internalization
GO:0001919--P:regulation of receptor recycling
GO:0009611--P:response to wounding
GO:0060041--P:retina development in camera-type eye
GO:0044281--P:small molecule metabolic process
GO:0007416--P:synapse assembly
GO:0007268--P:synaptic transmission