| Tag |
Content |
| dbPAF ID |
dbPAF-0006890 |
| Uniprot Accession |
P21757; MSRE_HUMAN; D3DSP3; O60505; P21759; Q45F10;
|
| Genbank Protein ID |
NP_002436.1; NP_619729.1; NP_619730.1;
|
| Genbank Nucleotide ID |
NM_002445.3; NM_138715.2; NM_138716.2;
|
| Protein Name |
Macrophage scavenger receptor types I and II |
| Protein Synonyms/Alias |
Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1; |
| Gene Name |
MSR1 |
| Gene Synonyms/Alias |
SCARA1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.Functional Description
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV 60
FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN 120
MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL 180
ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI 240
KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG 300
PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE 360
GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF 420
GRESSIEECK IRQWGTRACS HSEDAGVTCT L
452Fasta Sequence
>P21757|MSR1|Homo sapiens(Human)
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL
|
| Keyword |
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0176--Collagen
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0254--Endocytosis
KW-0325--Glycoprotein
KW-0427--LDL
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR008160--Collagen
IPR003543--Macro_scav_rcpt
IPR001190--SRCR
IPR017448--SRCR-like_dom
|
| PROSITE |
PS00420--SRCR_1
PS50287--SRCR_2
|
| Pfam |
PF01391--Collagen
PF03523--Macscav_rec
PF00530--SRCR
|
| Gene Ontology |
GO:0005581--C:collagen trimer
GO:0005829--C:cytosol
GO:0030666--C:endocytic vesicle membrane
GO:0005887--C:integral component of plasma membrane
GO:0034362--C:low-density lipoprotein particle
GO:0005886--C:plasma membrane
GO:0030169--F:low-density lipoprotein particle binding
GO:0005044--F:scavenger receptor activity
GO:0071407--P:cellular response to organic cyclic compound
GO:0030301--P:cholesterol transport
GO:0042953--P:lipoprotein transport
GO:0034381--P:plasma lipoprotein particle clearance
GO:0010886--P:positive regulation of cholesterol storage
GO:0010744--P:positive regulation of macrophage derived foam cell differentiation
GO:0006898--P:receptor-mediated endocytosis
|
