dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006883
Uniprot Accession P21709; EPHA1_HUMAN; A1L3V3; B5A966; B5A967; Q15405;
Genbank Protein ID NP_005223.4;
Genbank Nucleotide ID NM_005232.4;
Protein Name Ephrin type-A receptor 1
Protein Synonyms/Alias
Gene Name EPHA1
Gene Synonyms/Alias EPH;EPHT;EPHT1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
33KEVTLMDTSKAQGELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated16964243; 16381945; 23193290; 18988627; 22135298; 19366988;
34EVTLMDTSKAQGELGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated16964243; 16381945; 23193290; 18988627; 22135298; 19366988;
153TTVAADQSFTIRDLVPhosphoSitePlus22135298
155VAADQSFTIRDLVSGPhosphoSitePlus22135298
599DKLWLKPYVDLQAYEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 20736484; 22322096; 16381945; 23193290; 19060867;
605PYVDLQAYEDPAQGAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 20736484; 22322096; 16381945; 23193290; 19060867;
780LLDDFDGTYETQGGKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 19060867; 22135298; 26267517
781LDDFDGTYETQGGKIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15951569; 16381945; 23193290; 17389395; 18083107; 18180459;
783DFDGTYETQGGKIPIPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
805IAHRIFTTASDVWSFPhosphoSitePlus22135298
811TTASDVWSFGIVMWEPhosphoSitePlus22135298
892ANPHSLRTIANFDPRPhosphoSitePlus22135298
906RMTLRLPSLSGSDGIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 19664994; 21406692; 18988627;
908TLRLPSLSGSDGIPYdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298;
910RLPSLSGSDGIPYRTdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 19664994; 21406692; 18988627;
919GIPYRTVSEWLESIRdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298;
Sequence
(Fasta)		MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG 60
TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 120
TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG 180
LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR 240
PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ 300
STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG 360
RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE 420
AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT 480
YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS 540
RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV 600
DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD 660
TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ 720
LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT 780
YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE 840
DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM 900
TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL 960
PGHQKRILCS IQGFKD 977
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0067--ATP-binding
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR027936--Eph_TM
IPR001090--Ephrin_rcpt_lig-bd_dom
IPR003961--FN3_dom
IPR008979--Galactose-bd-like
IPR009030--Growth_fac_rcpt_N_dom
IPR013783--Ig-like_fold
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001660--SAM
IPR013761--SAM/pointed
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR016257--Tyr_kinase_ephrin_rcpt
IPR001426--Tyr_kinase_rcpt_V_CS
PROSITE

PS01186--EGF_2
PS51550--EPH_LBD
PS50853--FN3
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS00790--RECEPTOR_TYR_KIN_V_1
PS00791--RECEPTOR_TYR_KIN_V_2
PS50105--SAM_DOMAIN
Pfam

PF14575--EphA2_TM
PF01404--Ephrin_lbd
PF00041--fn3
PF07714--Pkinase_Tyr
PF00536--SAM_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0005005--F:transmembrane-ephrin receptor activity
GO:0090630--P:activation of GTPase activity
GO:0001525--P:angiogenesis
GO:0007411--P:axon guidance
GO:0007166--P:cell surface receptor signaling pathway
GO:0048013--P:ephrin receptor signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0006469--P:negative regulation of protein kinase activity
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0045766--P:positive regulation of angiogenesis
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0001954--P:positive regulation of cell-matrix adhesion
GO:0051496--P:positive regulation of stress fiber assembly
GO:0046777--P:protein autophosphorylation
GO:0043087--P:regulation of GTPase activity
GO:0035019--P:somatic stem cell population maintenance
GO:0034446--P:substrate adhesion-dependent cell spreading