dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006862
Uniprot Accession P21579; SYT1_HUMAN; Q6AI31;
Genbank Protein ID NP_001129277.1; NP_001129278.1; NP_005630.1; XP_011537012.1;
Genbank Nucleotide ID NM_001135805.1; NM_001135806.1; NM_005639.2; XM_011538710.1;
Protein Name Synaptotagmin-1
Protein Synonyms/Alias Synaptotagmin I;SytI;p65;
Gene Name SYT1
Gene Synonyms/Alias SVP65;SYT;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
24TVATVLPSNATEPASPhosphoSitePlus22135298
126LKDDDAETGLTDGEEdbPTM 3.0;PhosphoSitePlus;curated18510355; 16381945; 23193290; 22135298; 22817900
129DDAETGLTDGEEKEEdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18510355; 21406692; 16381945; 23193290; 18988627; 22135298;
181MGGTSDPYVKVFLLPPhosphoSitePlus22135298
202ETKVHRKTLNPVFNEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 22817900
212PVFNEQFTFKVPYSEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 22817900
217QFTFKVPYSELGGKTPhosphoSitePlus22135298
230KTLVMAVYDFDRFSKPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
312VGGLSDPYVKIHLMQPhosphoSitePlus;curated22135298; 22817900
329KRLKKKKTTIKKNTLPhosphoSitePlus;curated22135298; 22817900
330RLKKKKTTIKKNTLNPhosphoSitePlus;curated22135298; 22817900
365VVVTVLDYDKIGKNDPhosphoPep 2.019060867
381IGKVFVGYNSTGAELPhosphoPep 2.019060867
Sequence
(Fasta)		MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE LHKIPLPPWA 60
LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN AINMKDVKDL GKTMKDQALK 120
DDDAETGLTD GEEKEEPKEE EKLGKLQYSL DYDFQNNQLL VGIIQAAELP ALDMGGTSDP 180
YVKVFLLPDK KKKFETKVHR KTLNPVFNEQ FTFKVPYSEL GGKTLVMAVY DFDRFSKHDI 240
IGEFKVPMNT VDFGHVTEEW RDLQSAEKEE QEKLGDICFS LRYVPTAGKL TVVILEAKNL 300
KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT IKKNTLNPYY NESFSFEVPF EQIQKVQVVV 360
TVLDYDKIGK NDAIGKVFVG YNSTGAELRH WSDMLANPRR PIAQWHTLQV EEEVDAMLAV 420
KK 423
Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000008--C2_dom
IPR001565--Synaptotagmin
IPR015428--Synaptotagmin1
PROSITE

PS50004--C2
Pfam

PF00168--C2
Gene Ontology

GO:0030054--C:cell junction
GO:0042584--C:chromaffin granule membrane
GO:0060201--C:clathrin-sculpted acetylcholine transport vesicle membrane
GO:0061202--C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0060203--C:clathrin-sculpted glutamate transport vesicle membrane
GO:0070083--C:clathrin-sculpted monoamine transport vesicle membrane
GO:0016021--C:integral component of membrane
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0005545--F:1-phosphatidylinositol binding
GO:0005509--F:calcium ion binding
GO:0005544--F:calcium-dependent phospholipid binding
GO:0030276--F:clathrin binding
GO:0050750--F:low-density lipoprotein particle receptor binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0000149--F:SNARE binding
GO:0017075--F:syntaxin-1 binding
GO:0048791--P:calcium ion-dependent exocytosis of neurotransmitter
GO:0005513--P:detection of calcium ion
GO:0098746--P:fast, calcium ion-dependent exocytosis of neurotransmitter
GO:0014047--P:glutamate secretion
GO:0007269--P:neurotransmitter secretion
GO:1903861--P:positive regulation of dendrite extension
GO:0050806--P:positive regulation of synaptic transmission
GO:0051260--P:protein homooligomerization
GO:0017158--P:regulation of calcium ion-dependent exocytosis
GO:0017157--P:regulation of exocytosis
GO:1903305--P:regulation of regulated secretory pathway
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0007268--P:synaptic transmission
GO:0048488--P:synaptic vesicle endocytosis
GO:0016079--P:synaptic vesicle exocytosis