dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006856
Uniprot Accession P21554; CNR1_HUMAN; B2R9T4; E1P512; Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0;
Genbank Protein ID NP_001153698.1; NP_001153730.1; NP_001153731.1; NP_057167.2; NP_149421.2; XP_005248707.1; XP_006715393.1; XP_011533726.1; XP_011533727.1; XP_011533728.1; XP_011533729.1; XP_011533730.1;
Genbank Nucleotide ID NM_001160226.1; NM_001160258.1; NM_001160259.1; NM_016083.4; NM_033181.3; XM_005248650.3; XM_006715330.2; XM_011535424.1; XM_011535425.1; XM_011535426.1; XM_011535427.1; XM_011535428.1;
Protein Name Cannabinoid receptor 1
Protein Synonyms/Alias
Gene Name CNR1
Gene Synonyms/Alias CNR;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
15LADTTFRTITTDLLYPhosphoSitePlus22135298
224SIHRPLAYKRIVTRPPhosphoSitePlus22135298
344MDIRLAKTLVLILVVPhosphoSitePlus22135298
425TAQPLDNSMGDSDCLdbPTM 3.0;PhosphoSitePlus;curated17910957; 16381945; 23193290; 22135298; 22817900
429LDNSMGDSDCLHKHAdbPTM 3.0;PhosphoSitePlus;curated17910957; 16381945; 23193290; 22135298; 22817900; 24260401
460TVKIAKVTMSVSTDTPhosphoSitePlus22135298
464AKVTMSVSTDTSAEAPhosphoSitePlus22135298
465KVTMSVSTDTSAEALPhosphoSitePlus22135298
Sequence
(Fasta)		MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 60
KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 120
VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 180
HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM 240
WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 300
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 360
AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 420
PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL 473
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000810--Canbinoid_rcpt_1
IPR002230--Cnbnoid_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
Gene Ontology

GO:0030424--C:axon
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0004949--F:cannabinoid receptor activity
GO:0008144--F:drug binding
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007568--P:aging
GO:0007413--P:axonal fasciculation
GO:0038171--P:cannabinoid signaling pathway
GO:0007187--P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0042593--P:glucose homeostasis
GO:0060135--P:maternal process involved in female pregnancy
GO:0007613--P:memory
GO:0045759--P:negative regulation of action potential
GO:0045776--P:negative regulation of blood pressure
GO:0033602--P:negative regulation of dopamine secretion
GO:0031999--P:negative regulation of fatty acid beta-oxidation
GO:0033004--P:negative regulation of mast cell activation
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0002866--P:positive regulation of acute inflammatory response to antigenic stimulus
GO:0043065--P:positive regulation of apoptotic process
GO:0045777--P:positive regulation of blood pressure
GO:0031622--P:positive regulation of fever generation
GO:0010976--P:positive regulation of neuron projection development
GO:0060259--P:regulation of feeding behavior
GO:0050796--P:regulation of insulin secretion
GO:0060405--P:regulation of penile erection
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0042220--P:response to cocaine
GO:0045471--P:response to ethanol
GO:0032496--P:response to lipopolysaccharide
GO:0043278--P:response to morphine
GO:0035094--P:response to nicotine
GO:0007584--P:response to nutrient
GO:0019233--P:sensory perception of pain
GO:0007283--P:spermatogenesis