| Tag |
Content |
| dbPAF ID |
dbPAF-0006815 |
| Uniprot Accession |
P21246; PTN_HUMAN; Q5U0B0; Q6ICQ5; Q9UCC6;
|
| Genbank Protein ID |
NP_002816.1; XP_005250572.1;
|
| Genbank Nucleotide ID |
NM_002825.5; XM_005250515.2;
|
| Protein Name |
Pleiotrophin |
| Protein Synonyms/Alias |
|
| Gene Name |
PTN |
| Gene Synonyms/Alias |
HBNF1;NEGF1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.Functional Description
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW QWSVCVPTSG 60
DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK YQFQAWGECD LNTALKTRTG 120
SLKRALHNAE CQKTVTISKP CGKLTKPKPQ AESKKKKKEG KKQEKMLD
169Fasta Sequence
>P21246|PTN|Homo sapiens(Human)
MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD
|
| Keyword |
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0339--Growth factor
KW-0358--Heparin-binding
KW-0497--Mitogen
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR000762--Midkine_heparin-bd_GF
IPR020090--PTN/MK_C_dom
IPR020091--PTN/MK_diS
IPR020089--PTN/MK_N_dom
IPR020092--PTN_MK_heparin-bd_GF_CS
|
| PROSITE |
PS00619--PTN_MK_1
PS00620--PTN_MK_2
|
| Pfam |
PF01091--PTN_MK_C
PF05196--PTN_MK_N
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0008201--F:heparin binding
GO:0004864--F:protein phosphatase inhibitor activity
GO:0030282--P:bone mineralization
GO:0071456--P:cellular response to hypoxia
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071305--P:cellular response to vitamin D
GO:0030902--P:hindbrain development
GO:0007612--P:learning
GO:0001889--P:liver development
GO:0060291--P:long-term synaptic potentiation
GO:0030324--P:lung development
GO:0043086--P:negative regulation of catalytic activity
GO:0045837--P:negative regulation of membrane potential
GO:0007399--P:nervous system development
GO:0051781--P:positive regulation of cell division
GO:0008284--P:positive regulation of cell proliferation
GO:0010811--P:positive regulation of cell-substrate adhesion
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0014823--P:response to activity
GO:0042493--P:response to drug
GO:1990089--P:response to nerve growth factor
GO:0060221--P:retinal rod cell differentiation
GO:0071340--P:skeletal muscle acetylcholine-gated channel clustering
GO:0021510--P:spinal cord development
GO:0007185--P:transmembrane receptor protein tyrosine phosphatase signaling pathway
|
