dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006812 |
| Uniprot Accession | P21217; FUT3_HUMAN; B5U7U9; B5U7V0; Q32NE7; Q99448; Q99449; |
| Genbank Protein ID | NP_000140.1; NP_001091108.1; NP_001091109.1; NP_001091110.1; XP_011526167.1; XP_011526168.1; XP_011526169.1; |
| Genbank Nucleotide ID | NM_000149.3; NM_001097639.1; NM_001097640.1; NM_001097641.1; XM_011527865.1; XM_011527866.1; XM_011527867.1; |
| Protein Name | Galactoside 3(4)-L-fucosyltransferase |
| Protein Synonyms/Alias | Blood group Lewis alpha-4-fucosyltransferase;Lewis FT;Fucosyltransferase 3;Fucosyltransferase III;FucT-III; |
| Gene Name | FUT3 |
| Gene Synonyms/Alias | FT3B;LE; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. |
| Phosphorylation Sites |
dbPAF PTMs: 6 |
| Sequence (Fasta) | MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG SSRQDTTPTR 60 PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY PQADTVIVHH WDIMSNPKSR 120 LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA 180 HPPLNLSAKT ELVAWAVSNW KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR 240 YKFYLAFENS LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK 300 DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY QTVRSIAAWF 360 T 362 |
| Keyword | KW-0095--Blood group antigen |
| Interpro | |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0070062--C:extracellular exosome |