dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006794
Uniprot Accession P20936; RASA1_HUMAN; B2R6W3; B4DTL2; Q68CU6; Q9UDI1;
Genbank Protein ID NP_002881.1; NP_072179.1;
Genbank Nucleotide ID NM_002890.2; NM_022650.2;
Protein Name Ras GTPase-activating protein 1
Protein Synonyms/Alias
Gene Name RASA1
Gene Synonyms/Alias GAP;RASA;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
164DSLDGPEYEEEEVAIdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
239IIAMCGDYYIGGRRFdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 19060867; 22135298; 22817900
240IAMCGDYYIGGRRFScurated24961811
418MGGRYYNSIGDIIDHcurated23898821
453QEQVLNDTVDGKEIYPhosphoSitePlus22135298
460TVDGKEIYNTIRRKTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated1850098; 16381945; 23193290; 18988627; 22135298; 25627689; 2
462DGKEIYNTIRRKTKDPhosphoSitePlus22135298
472RKTKDAFYKNIVKKGPhosphoSitePlus22135298
612KLPVKHFTNPYCNIYPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
615VKHFTNPYCNIYLNSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated15592455; 18083107; 16381945; 23193290; 20090780; 21253578;
754QDRTLLASILLRIFLPhosphoSitePlus22135298
827KIMESKQSCELSPSKdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
831SKQSCELSPSKLEKNPhosphoSitePlus;curated22135298; 25627689; 23917254
952EFGAKEPYMEGVNPFPhosphoSitePlus22135298
Sequence
(Fasta)		MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT 60
LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP 120
TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ 180
WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY 240
IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS 300
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE 360
AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG 420
DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY 480
LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC 540
FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI 600
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN 660
KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE 720
EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM 780
EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED 840
VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV 900
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI 960
KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ 1020
HVLKKLLAIT ELLQQKQNQY TKTNDVR 1048
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
Interpro

IPR000008--C2_dom
IPR028554--p120-RasGAP
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR023152--RasGAP_CS
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
IPR000980--SH2
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS00509--RAS_GTPASE_ACTIV_1
PS50018--RAS_GTPASE_ACTIV_2
PS50001--SH2
PS50002--SH3
Pfam

PF00168--C2
PF00169--PH
PF00616--RasGAP
PF00017--SH2
PF00018--SH3_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031235--C:intrinsic component of the cytoplasmic side of the plasma membrane
GO:0001726--C:ruffle
GO:0001948--F:glycoprotein binding
GO:0005096--F:GTPase activator activity
GO:0051020--F:GTPase binding
GO:0019870--F:potassium channel inhibitor activity
GO:0005102--F:receptor binding
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0048514--P:blood vessel morphogenesis
GO:0009790--P:embryo development
GO:0048013--P:ephrin receptor signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0000165--P:MAPK cascade
GO:0000281--P:mitotic cytokinesis
GO:0007162--P:negative regulation of cell adhesion
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction
GO:0030833--P:regulation of actin filament polymerization
GO:0008360--P:regulation of cell shape
GO:0051252--P:regulation of RNA metabolic process
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0001570--P:vasculogenesis