dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006792
Uniprot Accession P20933; ASPG_HUMAN; B2R7H2; D3DP47; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8;
Genbank Protein ID NP_000018.2; NP_001165459.1;
Genbank Nucleotide ID NM_000027.3; NM_001171988.1;
Protein Name N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Protein Synonyms/Alias Aspartylglucosaminidase;Glycosylasparaginase;N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase;
Gene Name AGA
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
178VIPDPSKYCGPYKPPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated9362483; 16381945; 23193290; 22135298; 22817900
215GMVVIHKTGHIAAGTPhosphoSitePlus22135298
324CNKLSTFTQFSFMVYPhosphoSitePlus22135298
Sequence
(Fasta)		MARKSNLPVL LVPFLLCQAL VRCSSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG 60
CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE 120
HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG 180
PYKPPGILKQ DIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI 240
PGAGAYADDT AGAAAATGNG DILMRFLPSY QAVEYMRRGE DPTIACQKVI SRIQKHFPEF 300
FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTE EKVDCI 347
Keyword

KW-0002--3D-structure
KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
Interpro

IPR029055--Ntn_hydrolases_N
IPR000246--Peptidase_T2
PROSITE
Pfam

PF01112--Asparaginase_2
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005764--C:lysosome
GO:0003948--F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0008233--F:peptidase activity
GO:0006517--P:protein deglycosylation
GO:0051604--P:protein maturation