| Tag |
Content |
| dbPAF ID |
dbPAF-0006787 |
| Uniprot Accession |
P20916; MAG_HUMAN; B7Z2E5; F5GYC0; Q567S4;
|
| Genbank Protein ID |
NP_001186145.1; NP_002352.1; NP_542167.1;
|
| Genbank Nucleotide ID |
NM_001199216.1; NM_002361.3; NM_080600.2;
|
| Protein Name |
Myelin-associated glycoprotein |
| Protein Synonyms/Alias |
Siglec-4a; |
| Gene Name |
MAG |
| Gene Synonyms/Alias |
GMA; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).Functional Description
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 60
FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD 120
LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 180
GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP 240
VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED 300
GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF 360
KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH 420
CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA 480
QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 540
NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS 600
DLGKRPTKDS YTLTEELAEY AEIRVK
627Fasta Sequence
>P20916|MAG|Homo sapiens(Human)
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
|
| Keyword |
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0430--Lectin
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR013162--CD80_C2-set
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR003598--Ig_sub2
|
| PROSITE |
PS50835--IG_LIKE
|
| Pfam |
PF08205--C2-set_2
PF07679--I-set
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0097453--C:mesaxon
GO:0035749--C:myelin sheath adaxonal region
GO:0033270--C:paranode region of axon
GO:0005886--C:plasma membrane
GO:0043220--C:Schmidt-Lanterman incisure
GO:0030246--F:carbohydrate binding
GO:0007596--P:blood coagulation
GO:0007155--P:cell adhesion
GO:0071260--P:cellular response to mechanical stimulus
GO:0050900--P:leukocyte migration
GO:0050771--P:negative regulation of axonogenesis
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0031643--P:positive regulation of myelination
GO:0050770--P:regulation of axonogenesis
GO:0021762--P:substantia nigra development
|
