| Tag |
Content |
| dbPAF ID |
dbPAF-0006779 |
| Uniprot Accession |
P20827; EFNA1_HUMAN; D3DV86; Q5SR60; Q5SR61; Q6I9T9; Q8N578;
|
| Genbank Protein ID |
NP_004419.2; NP_872626.1;
|
| Genbank Nucleotide ID |
NM_004428.2; NM_182685.1;
|
| Protein Name |
Ephrin-A1 |
| Protein Synonyms/Alias |
EPH-related receptor tyrosine kinase ligand 1;LERK-1;Immediate early response protein B61;Tumor necrosis factor alpha-induced protein 4;TNF alpha-induced protein 4; |
| Gene Name |
EFNA1 |
| Gene Synonyms/Alias |
EPLG1;LERK1;TNFAIP4; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.Functional Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MEFLWAPLLG LCCSLAAADR HTVFWNSSNP KFRNEDYTIH VQLNDYVDII CPHYEDHSVA 60
DAAMEQYILY LVEHEEYQLC QPQSKDQVRW QCNRPSAKHG PEKLSEKFQR FTPFTLGKEF 120
KEGHSYYYIS KPIHQHEDRC LRLKVTVSGK ITHSPQAHDN PQEKRLAADD PEVRVLHSIG 180
HSAAPRLFPL AWTVLLLPLL LLQTP
206Fasta Sequence
>P20827|EFNA1|Homo sapiens(Human)
MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0043--Tumor suppressor
|
| Interpro |
IPR008972--Cupredoxin
IPR031328--Ephrin
IPR019765--Ephrin_CS
IPR001799--Ephrin_RBD
|
| PROSITE |
PS01299--EPHRIN_RBD_1
PS51551--EPHRIN_RBD_2
|
| Pfam |
PF00812--Ephrin
|
| Gene Ontology |
GO:0046658--C:anchored component of plasma membrane
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0046875--F:ephrin receptor binding
GO:0005102--F:receptor binding
GO:0000187--P:activation of MAPK activity
GO:0001525--P:angiogenesis
GO:0003180--P:aortic valve morphogenesis
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0007267--P:cell-cell signaling
GO:0003199--P:endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0048013--P:ephrin receptor signaling pathway
GO:0003183--P:mitral valve morphogenesis
GO:0061002--P:negative regulation of dendritic spine morphogenesis
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0014028--P:notochord formation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045765--P:regulation of angiogenesis
GO:0050770--P:regulation of axonogenesis
GO:0043535--P:regulation of blood vessel endothelial cell migration
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050730--P:regulation of peptidyl-tyrosine phosphorylation
GO:0034446--P:substrate adhesion-dependent cell spreading
|
