dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006758
Uniprot Accession P20749; BCL3_HUMAN;
Genbank Protein ID NP_005169.2; XP_011525499.1;
Genbank Nucleotide ID NM_005178.4; XM_011527197.1;
Protein Name B-cell lymphoma 3 protein
Protein Synonyms/Alias
Gene Name BCL3
Gene Synonyms/Alias BCL4;D19S37;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Phosphorylation Sites
dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
41KRPLRAPSPEPAAPRdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17322306; 16381945; 23193290; 18988627; 22135298; 19366988;
83LARPEALYYPGALLPPhosphoSitePlus22135298
84ARPEALYYPGALLPLPhosphoSitePlus22135298
374STSQPDPSPDRSANTPhosphoSitePlus;curated22135298; 25627689; 23911959; 23898821; 24129246; 23186163;
378PDPSPDRSANTSPEScurated23898821
381SPDRSANTSPESSSRcurated23898821
382PDRSANTSPESSSRLcurated23898821; 25849741
386ANTSPESSSRLSSNGPhosphoSitePlus22135298
387NTSPESSSRLSSNGLPhosphoSitePlus22135298
402LSASPSSSPSQSPPRdbPTM 3.0;PhosphoSitePlus16381945; 23193290; 15469820; 22135298
406PSSSPSQSPPRDPPGdbPTM 3.0;PhosphoSitePlus15469820; 16381945; 23193290; 22135298
448PGRPVPPSPAPGGS-PhosphoSitePlus22135298
454PSPAPGGS-------PhosphoSitePlus22135298
Sequence
(Fasta)
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL 60
RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP 120
LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV 180
ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY 240
DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 300
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG 360
KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN 420
FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS 455
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0040--ANK repeat
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT

Pfam

PF12796--Ank_2

Gene Ontology

GO:0032996--C:Bcl3-Bcl10 complex
GO:0033257--C:Bcl3/NF-kappaB2 complex
GO:0005737--C:cytoplasm
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003677--F:DNA binding
GO:0030674--F:protein binding, bridging
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0019730--P:antimicrobial humoral response
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042742--P:defense response to bacterium
GO:0042832--P:defense response to protozoan
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0030198--P:extracellular matrix organization
GO:0002268--P:follicular dendritic cell differentiation
GO:0002467--P:germinal center formation
GO:0002455--P:humoral immune response mediated by circulating immunoglobulin
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0051457--P:maintenance of protein location in nucleus
GO:0002315--P:marginal zone B cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:0045415--P:negative regulation of interleukin-8 biosynthetic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042536--P:negative regulation of tumor necrosis factor biosynthetic process
GO:0032729--P:positive regulation of interferon-gamma production
GO:0045082--P:positive regulation of interleukin-10 biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045727--P:positive regulation of translation
GO:0000060--P:protein import into nucleus, translocation
GO:0042981--P:regulation of apoptotic process
GO:0051101--P:regulation of DNA binding
GO:0042345--P:regulation of NF-kappaB import into nucleus
GO:0010225--P:response to UV-C
GO:0009615--P:response to virus
GO:0048536--P:spleen development
GO:0042088--P:T-helper 1 type immune response
GO:0045064--P:T-helper 2 cell differentiation
GO:0006351--P:transcription, DNA-templated