Tag |
Content |
dbPAF ID |
dbPAF-0006758 |
Uniprot Accession |
P20749; BCL3_HUMAN; |
Genbank Protein ID |
NP_005169.2; XP_011525499.1; |
Genbank Nucleotide ID |
NM_005178.4; XM_011527197.1; |
Protein Name |
B-cell lymphoma 3 protein |
Protein Synonyms/Alias |
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Gene Name |
BCL3 |
Gene Synonyms/Alias |
BCL4;D19S37; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).Functional Description
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
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Phosphorylation Sites
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dbPAF PTMs: 13 |
Sequence (Fasta) | MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL 60 RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP 120 LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV 180 ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY 240 DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 300 NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG 360 KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN 420 FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS
455Fasta Sequence
>P20749|BCL3|Homo sapiens(Human) MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
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Keyword |
KW-0002--3D-structure KW-0010--Activator KW-0040--ANK repeat KW-0160--Chromosomal rearrangement KW-0181--Complete proteome KW-0963--Cytoplasm KW-0539--Nucleus KW-0597--Phosphoprotein KW-0656--Proto-oncogene KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation
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Interpro |
IPR002110--Ankyrin_rpt IPR020683--Ankyrin_rpt-contain_dom
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PROSITE |
PS50297--ANK_REP_REGION PS50088--ANK_REPEAT
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Pfam |
PF12796--Ank_2
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Gene Ontology |
GO:0032996--C:Bcl3-Bcl10 complex GO:0033257--C:Bcl3/NF-kappaB2 complex GO:0005737--C:cytoplasm GO:0045171--C:intercellular bridge GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0048471--C:perinuclear region of cytoplasm GO:0043234--C:protein complex GO:0003677--F:DNA binding GO:0030674--F:protein binding, bridging GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0008134--F:transcription factor binding GO:0019730--P:antimicrobial humoral response GO:0006974--P:cellular response to DNA damage stimulus GO:0042742--P:defense response to bacterium GO:0042832--P:defense response to protozoan GO:0030330--P:DNA damage response, signal transduction by p53 class mediator GO:0030198--P:extracellular matrix organization GO:0002268--P:follicular dendritic cell differentiation GO:0002467--P:germinal center formation GO:0002455--P:humoral immune response mediated by circulating immunoglobulin GO:0007249--P:I-kappaB kinase/NF-kappaB signaling GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0051457--P:maintenance of protein location in nucleus GO:0002315--P:marginal zone B cell differentiation GO:0043066--P:negative regulation of apoptotic process GO:0045415--P:negative regulation of interleukin-8 biosynthetic process GO:0045892--P:negative regulation of transcription, DNA-templated GO:0042536--P:negative regulation of tumor necrosis factor biosynthetic process GO:0032729--P:positive regulation of interferon-gamma production GO:0045082--P:positive regulation of interleukin-10 biosynthetic process GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0045727--P:positive regulation of translation GO:0000060--P:protein import into nucleus, translocation GO:0042981--P:regulation of apoptotic process GO:0051101--P:regulation of DNA binding GO:0042345--P:regulation of NF-kappaB import into nucleus GO:0010225--P:response to UV-C GO:0009615--P:response to virus GO:0048536--P:spleen development GO:0042088--P:T-helper 1 type immune response GO:0045064--P:T-helper 2 cell differentiation GO:0006351--P:transcription, DNA-templated
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