dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006753
Uniprot Accession P20700; LMNB1_HUMAN; B2R6J6; Q3SYN7; Q96EI6;
Genbank Protein ID NP_005564.1;
Genbank Nucleotide ID NM_005573.3;
Protein Name Lamin-B1
Protein Synonyms/Alias
Gene Name LMNB1
Gene Synonyms/Alias LMN2;LMNB;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Phosphorylation Sites
 dbPAF PTMs: 51 (View all)
PositionPeptidesSourceReferences ( PMIDs )
3-----MATATPVPPRdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated19664995; 20068231; 16381945; 23193290; 19691289; 18988627;
5---MATATPVPPRMGdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated19413330; 16381945; 23193290; 19664995; 20068231; 18988627;
13PVPPRMGSRAGGPTTdbPTM 3.0;PhosphoSitePlus;curated18187866; 16381945; 23193290; 22135298; 23090842; 22817900;
19GSRAGGPTTPLSPTRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18669648; 19664995; 21659604;
20SRAGGPTTPLSPTRLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 16964243; 18669648; 18691976; 19413330; 19690332;
23GGPTTPLSPTRLSRLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 16964243; 17081983; 17287340; 18220336; 18669648;
25PTTPLSPTRLSRLQEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 22115753; 19651622; 20068231;
28PLSPTRLSRLQEKEEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 22135298;
46LNDRLAVYIDKVRSLPhosphoSitePlus22135298
58RSLETENSALQLQVTPhosphoSitePlus;curated22135298; 22817900; 23186163
126LNYAKKESDLNGAQIPHOSIDA;curated21081558; 22817900
138AQIKLREYEAALNSKPhosphoSitePlus22135298
158TALGDKKSLEGDLEDdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
200DLENRCQSLTEDLEFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 19060867;
210EDLEFRKSMYEEEINdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20068231; 21406692; 22115753; 16381945; 23193290; 18988627;
212LEFRKSMYEEEINETPhosphoSitePlus22135298
232TRLVEVDSGRQIEYEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298; 25627689;
267YKEELEQTYHAKLENPhosphoSitePlus22135298
268KEELEQTYHAKLENAPhosphoSitePlus22135298
278KLENARLSSEMNTSTdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19007248; 16381945; 23193290; 19691289; 20068231; 18988627;
Sequence
(Fasta)		MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL 60
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN 120
YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA 180
KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY 240
KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI 300
ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY 360
EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD 420
VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV 480
SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA 540
QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM 587
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0403--Intermediate filament
KW-1017--Isopeptide bond
KW-1026--Leukodystrophy
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR001664--IF
IPR018039--Intermediate_filament_CS
IPR027696--Lamin_B
IPR001322--Lamin_tail_dom
PROSITE

PS00226--IF
Pfam

PF00038--Filament
PF00932--LTD
Gene Ontology

GO:0005638--C:lamin filament
GO:0016020--C:membrane
GO:0005635--C:nuclear envelope
GO:0005637--C:nuclear inner membrane
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005198--F:structural molecule activity
GO:0006915--P:apoptotic process
GO:0006921--P:cellular component disassembly involved in execution phase of apoptosis
GO:0012501--P:programmed cell death