dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006702
Uniprot Accession P20339; RAB5A_HUMAN; B4DJA5; Q6FI44;
Genbank Protein ID NP_001278977.1; NP_004153.2;
Genbank Nucleotide ID NM_001292048.1; NM_004162.4;
Protein Name Ras-related protein Rab-5A
Protein Synonyms/Alias
Gene Name RAB5A
Gene Synonyms/Alias RAB5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
3-----MASRGATRPNPhosphoSitePlus;curated22135298; 25627689
7-MASRGATRPNGPNTPhosphoSitePlus22135298
51QFHEFQESTIGAAFLdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
123KELQRQASPNIVIALdbPTM 3.0;curated10403367; 16381945; 23193290; 25627689
193PQNPGANSARGRGVDcurated25262027
202RGRGVDLTEPTQPTRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
205GVDLTEPTQPTRNQCdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
208LTEPTQPTRNQCCSNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
Sequence
(Fasta)		MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ 60
TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR 120
QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK 180
LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN 216
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0636--Prenylation
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR003579--Small_GTPase_Rab_type
PROSITE

PS51419--RAB
Pfam

PF00071--Ras
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030424--C:axon
GO:0043679--C:axon terminus
GO:0005737--C:cytoplasm
GO:0098559--C:cytoplasmic side of early endosome membrane
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0030139--C:endocytic vesicle
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0042470--C:melanosome
GO:0045121--C:membrane raft
GO:0043025--C:neuronal cell body
GO:0045335--C:phagocytic vesicle
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0036477--C:somatodendritic compartment
GO:0008021--C:synaptic vesicle
GO:0043195--C:terminal bouton
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0007596--P:blood coagulation
GO:0045022--P:early endosome to late endosome transport
GO:0006897--P:endocytosis
GO:0006886--P:intracellular protein transport
GO:0045921--P:positive regulation of exocytosis
GO:0032482--P:Rab protein signal transduction
GO:2000286--P:receptor internalization involved in canonical Wnt signaling pathway
GO:0030100--P:regulation of endocytosis
GO:0051036--P:regulation of endosome size
GO:0051489--P:regulation of filopodium assembly
GO:2000300--P:regulation of synaptic vesicle exocytosis
GO:0036465--P:synaptic vesicle recycling