dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006666 |
| Uniprot Accession | P20095; PRP2_YEAST; D6W1I6; |
| Genbank Protein ID | NP_014408.1; |
| Genbank Nucleotide ID | NM_001183188.1; |
| Protein Name | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 |
| Protein Synonyms/Alias | Pre-mRNA-processing protein 2; |
| Gene Name | PRP2 |
| Gene Synonyms/Alias | RNA2;YNR011C;N2048; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MSSITSETGK RRVKRTYEVT RQNDNAVRIE PSSLGEEEDK EAKDKNSALQ LKRSRYDPNK 60 VFSNTNQGPE KNNLKGEQLG SQKKSSKYDE KITSNNELTT KKGLLGDSEN ETKYASSNSK 120 FNVEVTHKIK NAKEIDKINR QRMWEEQQLR NAMAGQSDHP DDITLEGSDK YDYVFDTDAM 180 IDYTNEEDDL LPEEKLQYEA RLAQALETEE KRILTIQEAR KLLPVHQYKD ELLQEIKKNQ 240 VLIIMGETGS GKTTQLPQYL VEDGFTDQGK LQIAITQPRR VAATSVAARV ADEMNVVLGK 300 EVGYQIRFED KTTPNKTVLK YMTDGMLLRE FLTDSKLSKY SCIMIDEAHE RTLATDILIG 360 LLKDILPQRP TLKLLISSAT MNAKKFSEFF DNCPIFNVPG RRYPVDIHYT LQPEANYIHA 420 AITTIFQIHT TQSLPGDILV FLTGQEEIER TKTKLEEIMS KLGSRTKQMI ITPIYANLPQ 480 EQQLKIFQPT PENCRKVVLA TNIAETSLTI DGIRYVIDPG FVKENSYVPS TGMTQLLTVP 540 CSRASVDQRA GRAGRVGPGK CFRIFTKWSY LHELELMPKP EITRTNLSNT VLLLLSLGVT 600 DLIKFPLMDK PSIPTLRKSL ENLYILGALN SKGTITRLGK MMCEFPCEPE FAKVLYTAAT 660 HEQCQGVLEE CLTIVSMLHE TPSLFIGQKR DAAASVLSEV ESDHILYLEI FNQWRNSKFS 720 RSWCQDHKIQ FKTMLRVRNI RNQLFRCSEK VGLVEKNDQA RMKIGNIAGY INARITRCFI 780 SGFPMNIVQL GPTGYQTMGR SSGGLNVSVH PTSILFVNHK EKAQRPSKYV LYQQLMLTSK 840 EFIRDCLVIP KEEWLIDMVP QIFKDLIDDK TNRGRR 877 |
| Keyword | KW-0007--Acetylation |
| Interpro | IPR011545--DEAD/DEAH_box_helicase_dom |
| PROSITE | PS00690--DEAH_ATP_HELICASE |
| Pfam | PF00270--DEAD |
| Gene Ontology | GO:0005737--C:cytoplasm |