dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006657 |
| Uniprot Accession | P20052; PHO80_YEAST; D6W266; Q06882; Q06883; |
| Genbank Protein ID | NP_014642.1; |
| Genbank Nucleotide ID | NM_001183255.1; |
| Protein Name | PHO85 cyclin PHO80 |
| Protein Synonyms/Alias | Aminoglycoside antibiotic sensitivity protein 3;Phosphate system cyclin PHO80; |
| Gene Name | PHO80 |
| Gene Synonyms/Alias | AGS3;TUP7;VAC5;YOL001W;O2505;UNB293; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Negatively regulates the expression of phosphate-starvation-responsive genes under phosphate-rich conditions. The PHO80-PHO85 cyclin-CDK holoenzyme phosphorylates and inactivates the transcription factor PHO4, by preventing its association with the transcription factor PHO2 and the nuclear import receptor PSE1, and by promoting association with the nuclear export receptor MSN5, excluding PHO4 from the nucleus. PHO80-PHO85 phosphorylates and inactivates protein kinase RIM15 by retaining it in the cytoplasm, antagonizing RIM15-induced entry into stationary phase. PHO80-PHO85 also phosphorylates and inactivates the calcineurin-responsive transcription factor CRZ1, linking PHO85 to calcium signaling. |
| Phosphorylation Sites |
dbPAF PTMs: 6 |
| Sequence (Fasta) | MESTSGERSE NIHEDQGIPK VILPADFNKC SRTDLVVLIS RMLVSLIAIN ENSATKKSDD 60 QITLTRYHSK IPPNISIFNY FIRLTKFSSL EHCVLMTSLY YIDLLQTVYP DFTLNSLTAH 120 RFLLTATTVA TKGLCDSFST NAHYAKVGGV RCHELNILEN DFLKRVNYRI IPRDHNITLC 180 SIEQKQKKFV IDKNALGSLD LDSYSYVNRP KSGYNVLDKY YRRIVQLVGS FNASPDKSRK 240 VDYVLPPNID IVSESGSQTT QLKGSSSPNS HSSQKRYSEA KDAHIYNKRS KPD 294 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR013922--Cyclin_PHO80-like |
| PROSITE | |
| Pfam | PF08613--Cyclin |
| Gene Ontology | GO:0000307--C:cyclin-dependent protein kinase holoenzyme complex |