dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006639
Uniprot Accession P19882; HSP60_YEAST; D6VYQ6;
Genbank Protein ID NP_013360.1;
Genbank Nucleotide ID NM_001182146.1;
Protein Name Heat shock protein 60, mitochondrial
Protein Synonyms/Alias CPN60;P66;Stimulator factor I 66 kDa component;
Gene Name HSP60
Gene Synonyms/Alias MIF4;YLR259C;L8479.10;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
22PLLRRAYSSHKELKFcurated25704821
23LLRRAYSSHKELKFGcurated25704821
100KLLQEVASKTNEAAGcurated22369663
102LQEVASKTNEAAGDGdbPTM 3.0;PhosphoGRID 2.0;UniProt17761666; 16381945; 23193290
141PMDLRRGSQVAVEKVcurated24603354; 22817900; 24961812; 23825934
203ITIREGRTLEDELEVcurated22817900; 19547744
351ITVTKEDTVILNGSGcurated22817900
373RIEQIKGSIDITTTNPhosphoGRID 2.0;curated19779198; 26040289; 22817900
378KGSIDITTTNSYEKEcurated26040289
379GSIDITTTNSYEKEKcurated26040289
381IDITTTNSYEKEKLQcurated26040289
382DITTTNSYEKEKLQEcurated26040289
395QERLAKLSGGVAVIRPhosphoGRID 2.0;curated19779198; 22817900
485ENAGEEGSVIIGKLIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21126336; 19366988; 22817900;
Sequence
(Fasta)		MLRSSVVRSR ATLRPLLRRA YSSHKELKFG VEGRASLLKG VETLAEAVAA TLGPKGRNVL 60
IEQPFGPPKI TKDGVTVAKS IVLKDKFENM GAKLLQEVAS KTNEAAGDGT TSATVLGRAI 120
FTESVKNVAA GCNPMDLRRG SQVAVEKVIE FLSANKKEIT TSEEIAQVAT ISANGDSHVG 180
KLLASAMEKV GKEGVITIRE GRTLEDELEV TEGMRFDRGF ISPYFITDPK SSKVEFEKPL 240
LLLSEKKISS IQDILPALEI SNQSRRPLLI IAEDVDGEAL AACILNKLRG QVKVCAVKAP 300
GFGDNRKNTI GDIAVLTGGT VFTEELDLKP EQCTIENLGS CDSITVTKED TVILNGSGPK 360
EAIQERIEQI KGSIDITTTN SYEKEKLQER LAKLSGGVAV IRVGGASEVE VGEKKDRYDD 420
ALNATRAAVE EGILPGGGTA LVKASRVLDE VVVDNFDQKL GVDIIRKAIT RPAKQIIENA 480
GEEGSVIIGK LIDEYGDDFA KGYDASKSEY TDMLATGIID PFKVVRSGLV DASGVASLLA 540
TTEVAIVDAP EPPAAAGAGG MPGGMPGMPG MM 573
Keyword

KW-0067--ATP-binding
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
KW-0809--Transit peptide
Interpro

IPR018370--Chaperonin_Cpn60_CS
IPR001844--Chaprnin_Cpn60
IPR002423--Cpn60/TCP-1
IPR027409--GroEL-like_apical_dom
IPR027413--GROEL-like_equatorial
PROSITE

PS00296--CHAPERONINS_CPN60
Pfam

PF00118--Cpn60_TCP1
Gene Ontology

GO:0005829--C:cytosol
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005759--C:mitochondrial matrix
GO:0042645--C:mitochondrial nucleoid
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0051087--F:chaperone binding
GO:0003688--F:DNA replication origin binding
GO:0003697--F:single-stranded DNA binding
GO:0051082--F:unfolded protein binding
GO:0006458--P:'de novo' protein folding
GO:0051131--P:chaperone-mediated protein complex assembly
GO:0045041--P:protein import into mitochondrial intermembrane space
GO:0051604--P:protein maturation
GO:0042026--P:protein refolding
GO:0050821--P:protein stabilization