dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006628
Uniprot Accession P19812; UBR1_YEAST; D6VUW7;
Genbank Protein ID NP_011700.1;
Genbank Nucleotide ID NM_001181313.1;
Protein Name E3 ubiquitin-protein ligase UBR1
Protein Synonyms/Alias N-end-recognizing protein;N-recognin-1;
Gene Name UBR1
Gene Synonyms/Alias PTR1;YGR184C;G7168;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
2------MSVADDDLGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated15665377; 16381945; 23193290; 19366988; 22369663; 26040289
286NDYMFDGTTTAKTSPPhosphoGRID 2.0;curated18407956; 19779198; 20377248
288YMFDGTTTAKTSPSNdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 25315811;
291DGTTTAKTSPSNSPEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 21126336; 20702584;
292GTTTAKTSPSNSPEAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 19779198; 19060867;
294TTAKTSPSNSPEASPcurated22817900; 20377248
296AKTSPSNSPEASPSLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 20702584; 19779198;
300PSNSPEASPSLAKIDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 20702584; 19779198;
302NSPEASPSLAKIDPEPhosphoGRID 2.019779198
459PYRYIDLSILADGNQcurated19823750
1196KFMKEHESEFDEQDNcurated26040289; 22369663; 22817900; 24961812; 25315811; 20377248
1398VRKRANFSHKDVSLIcurated23607784
1720RADRHEMTKHLNKNCdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
1938RNLDEDDSDDNDDSDPhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;UniProt;curated19684113; 21081558; 19060867; 19779198; 26040289; 25704821;
1944DSDDNDDSDEREIW-PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;curated19684113; 21081558; 19060867; 26040289; 25704821; 22369663;
Sequence
(Fasta)		MSVADDDLGS LQGHIRRTLR SIHNLPYFRY TRGPTERADM SRALKEFIYR YLYFVISNSG 60
ENLPTLFNAH PKQKLSNPEL TVFPDSLEDA VDIDKITSQQ TIPFYKIDES RIGDVHKHTG 120
RNCGRKFKIG EPLYRCHECG CDDTCVLCIH CFNPKDHVNH HVCTDICTEF TSGICDCGDE 180
EAWNSPLHCK AEEQENDISE DPATNADIKE EDVWNDSVNI ALVELVLAEV FDYFIDVFNQ 240
NIEPLPTIQK DITIKLREMT QQGKMYERAQ FLNDLKYEND YMFDGTTTAK TSPSNSPEAS 300
PSLAKIDPEN YTVIIYNDEY HNYSQATTAL RQGVPDNVHI DLLTSRIDGE GRAMLKCSQD 360
LSSVLGGFFA VQTNGLSATL TSWSEYLHQE TCKYIILWIT HCLNIPNSSF QTTFRNMMGK 420
TLCSEYLNAT ECRDMTPVVE KYFSNKFDKN DPYRYIDLSI LADGNQIPLG HHKILPESST 480
HSLSPLINDV ETPTSRTYSN TRLQHILYFD NRYWKRLRKD IQNVIIPTLA SSNLYKPIFC 540
QQVVEIFNHI TRSVAYMDRE PQLTAIRECV VQLFTCPTNA KNIFENQSFL DIVWSIIDIF 600
KEFCKVEGGV LIWQRVQKSN LTKSYSISFK QGLYTVETLL SKVHDPNIPL RPKEIISLLT 660
LCKLFNGAWK IKRKEGEHVL HEDQNFISYL EYTTSIYSII QTAEKVSEKS KDSIDSKLFL 720
NAIRIISSFL GNRSLTYKLI YDSHEVIKFS VSHERVAFMN PLQTMLSFLI EKVSLKDAYE 780
ALEDCSDFLK ISDFSLRSVV LCSQIDVGFW VRNGMSVLHQ ASYYKNNPEL GSYSRDIHLN 840
QLAILWERDD IPRIIYNILD RWELLDWFTG EVDYQHTVYE DKISFIIQQF IAFIYQILTE 900
RQYFKTFSSL KDRRMDQIKN SIIYNLYMKP LSYSKLLRSV PDYLTEDTTE FDEALEEVSV 960
FVEPKGLADN GVFKLKASLY AKVDPLKLLN LENEFESSAT IIKSHLAKDK DEIAKVVLIP 1020
QVSIKQLDKD ALNLGAFTRN TVFAKVVYKL LQVCLDMEDS TFLNELLHLV HGIFRDDELI 1080
NGKDSIPEAY LSKPICNLLL SIANAKSDVF SESIVRKADY LLEKMIMKKP NELFESLIAS 1140
FGNQYVNDYK DKKLRQGVNL QETEKERKRR LAKKHQARLL AKFNNQQTKF MKEHESEFDE 1200
QDNDVDMVGE KVYESEDFTC ALCQDSSSTD FFVIPAYHDH SPIFRPGNIF NPNEFMPMWD 1260
GFYNDDEKQA YIDDDVLEAL KENGSCGSRK VFVSCNHHIH HNCFKRYVQK KRFSSNAFIC 1320
PLCQTFSNCT LPLCQTSKAN TGLSLDMFLE SELSLDTLSR LFKPFTEENY RTINSIFSLM 1380
ISQCQGFDKA VRKRANFSHK DVSLILSVHW ANTISMLEIA SRLEKPYSIS FFRSREQKYK 1440
TLKNILVCIM LFTFVIGKPS MEFEPYPQQP DTVWNQNQLF QYIVRSALFS PVSLRQTVTE 1500
ALTTFSRQFL RDFLQGLSDA EQVTKLYAKA SKIGDVLKVS EQMLFALRTI SDVRMEGLDS 1560
ESIIYDLAYT FLLKSLLPTI RRCLVFIKVL HELVKDSENE TLVINGHEVE EELEFEDTAE 1620
FVNKALKMIT EKESLVDLLT TQESIVSHPY LENIPYEYCG IIKLIDLSKY LNTYVTQSKE 1680
IKLREERSQH MKNADNRLDF KICLTCGVKV HLRADRHEMT KHLNKNCFKP FGAFLMPNSS 1740
EVCLHLTQPP SNIFISAPYL NSHGEVGRNA MRRGDLTTLN LKRYEHLNRL WINNEIPGYI 1800
SRVMGDEFRV TILSNGFLFA FNREPRPRRI PPTDEDDEDM EEGEDGFFTE GNDEMDVDDE 1860
TGQAANLFGV GAEGIAGGGV RDFFQFFENF RNTLQPQGNG DDDAPQNPPP ILQFLGPQFD 1920
GATIIRNTNP RNLDEDDSDD NDDSDEREIW 1951
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02207--zf-UBR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071629--P:cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0090089--P:regulation of dipeptide transport
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway