dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006606
Uniprot Accession P19541; RDS2_YEAST; D6W3N4;
Genbank Protein ID NP_015192.1;
Genbank Nucleotide ID NM_001183947.1;
Protein Name Regulator of drug sensitivity 2
Protein Synonyms/Alias
Gene Name RDS2
Gene Synonyms/Alias YPL133C;LPI12C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism. Involved in the cell wall remodeling process and drug resistance.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
63MPSQHESSPNDNNIQcurated25315811
102STYGEELSPKLDSSLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 20702584; 19366988;
194VARQENRSPTIMSGScurated22369663; 22817900; 25315811; 19547744
196RQENRSPTIMSGSSNcurated22369663; 22817900
199NRSPTIMSGSSNSIScurated22817900
201SPTIMSGSSNSISKGcurated22817900
228LANANENSAPTPKEQPhosphoGRID 2.0;curated21126336; 26040289
231ANENSAPTPKEQFFLdbPTM 3.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22369663; 24961812
331FERMLLSYDRVFTSMcurated25315811
Sequence
(Fasta)		MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI AVPNEMPSQH 60
ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE LSPKLDSSLV NDTTSLLLPQ 120
QPVFVSENVG SEFSSLNEFL SMLENPLLTQ TSLSSSSASN VHLENGSQTT QSPLEYQNDN 180
RRDEIGVARQ ENRSPTIMSG SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA 240
ADPSTEMTPE HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST 300
IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE IYRANKEFAS 360
LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG QKAVLTSCSL RTKDGIRKRP 420
CCFSFTIRRD RYNIPICIVG NFIPLS 447
Keyword

KW-0961--Cell wall biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR000014--PAS
IPR001138--Zn2-C6_fun-type_DNA-bd
PROSITE

PS00463--ZN2_CY6_FUNGAL_1
PS50048--ZN2_CY6_FUNGAL_2
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0071555--P:cell wall organization
GO:0071466--P:cellular response to xenobiotic stimulus
GO:0061415--P:negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061414--P:positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
GO:0006366--P:transcription from RNA polymerase II promoter