dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006567
Uniprot Accession P19262; ODO2_YEAST; D6VSD1;
Genbank Protein ID NP_010432.3;
Genbank Nucleotide ID NM_001180455.3;
Protein Name Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Protein Synonyms/Alias 2-oxoglutarate dehydrogenase complex component E2;OGDC-E2;Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex;
Gene Name KGD2
Gene Synonyms/Alias YDR148C;YD8358.05C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
17AAKSLVKSKVARNVMcurated19823750
27ARNVMAASFVKRHAScurated19823750
34SFVKRHASTSLFKQAcurated22817900; 19547744
35FVKRHASTSLFKQANcurated19823750
46KQANKVESLGSIYLScurated22817900; 19547744
51VESLGSIYLSGKKIScurated22817900; 19547744
53SLGSIYLSGKKISVAcurated22817900; 19547744
236TPFPRTETRVKMNRMcurated20377248
340ATPKGLVTPVVRNAEdbPTM 3.0;PhosphoGRID 2.0;UniProt17761666; 16381945; 23193290
Sequence
(Fasta)		MLSRATRTAA AKSLVKSKVA RNVMAASFVK RHASTSLFKQ ANKVESLGSI YLSGKKISVA 60
ANPFSITSNR FKSTSIEVPP MAESLTEGSL KEYTKNVGDF IKEDELLATI ETDKIDIEVN 120
SPVSGTVTKL NFKPEDTVTV GEELAQVEPG EAPAEGSGES KPEPTEQAEP SQGVAARENS 180
SEETASKKEA APKKEAAPKK EVTEPKKADQ PKKTVSKAQE PPVASNSFTP FPRTETRVKM 240
NRMRLRIAER LKESQNTAAS LTTFNEVDMS ALMEMRKLYK DEIIKKTGTK FGFMGLFSKA 300
CTLAAKDIPA VNGAIEGDQI VYRDYTDISV AVATPKGLVT PVVRNAESLS VLDIENEIVR 360
LSHKARDGKL TLEDMTGGTF TISNGGVFGS LYGTPIINSP QTAVLGLHGV KERPVTVNGQ 420
IVSRPMMYLA LTYDHRLLDG REAVTFLKTV KELIEDPRKM LLW 464
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0450--Lipoyl
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0809--Transit peptide
KW-0816--Tricarboxylic acid cycle
Interpro

IPR003016--2-oxoA_DH_lipoyl-BS
IPR001078--2-oxoacid_DH_actylTfrase
IPR000089--Biotin_lipoyl
IPR023213--CAT-like_dom
IPR011053--Single_hybrid_motif
IPR006255--SucB
PROSITE

PS50968--BIOTINYL_LIPOYL
PS00189--LIPOYL
Pfam

PF00198--2-oxoacid_dh
PF00364--Biotin_lipoyl
Gene Ontology

GO:0042645--C:mitochondrial nucleoid
GO:0009353--C:mitochondrial oxoglutarate dehydrogenase complex
GO:0004149--F:dihydrolipoyllysine-residue succinyltransferase activity
GO:0006103--P:2-oxoglutarate metabolic process
GO:0033512--P:L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0000002--P:mitochondrial genome maintenance
GO:0006099--P:tricarboxylic acid cycle