dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006558
Uniprot Accession P19211; IF5A2_YEAST; D6VWL8;
Genbank Protein ID NP_012581.3;
Genbank Nucleotide ID NM_001181705.3;
Protein Name Eukaryotic translation initiation factor 5A-2
Protein Synonyms/Alias
Gene Name ANB1
Gene Synonyms/Alias HYP1;TIF51B;YJR047C;J1651;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
2------MSDEEHTFEdbPTM 3.0;UniProt;curated17330950; 18407956; 15665377; 16381945; 23193290; 19779198;
7-MSDEEHTFENADAGdbPTM 3.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 1903841; 22817900
19DAGASATYPMQCSALcurated24961812
24ATYPMQCSALRKNGFcurated22369663; 19795423
46CKIVDMSTSKTGKHGcurated22369663
47KIVDMSTSKTGKHGHPhosphoPep 2.0;curated19060867; 22369663
74GKKLEDLSPSTHNLEdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 19366988; 22817900
88EVPFVKRSEYQLLDIcurated26040289
90PFVKRSEYQLLDIDDcurated26040289
104DGYLSLMTMDGETKDcurated26040289
149MGEEAAISFKEAPRSdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MSDEEHTFEN ADAGASATYP MQCSALRKNG FVVIKGRPCK IVDMSTSKTG KHGHAKVHLV 60
TLDIFTGKKL EDLSPSTHNL EVPFVKRSEY QLLDIDDGYL SLMTMDGETK DDVKAPEGEL 120
GDSMQAAFDE GKDLMVTIIS AMGEEAAISF KEAPRSD 158
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0385--Hypusine
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0694--RNA-binding
Interpro

IPR012340--NA-bd_OB-fold
IPR014722--Rib_L2_dom2
IPR019769--Trans_elong_IF5A_hypusine_site
IPR001884--Transl_elong_IF5A
IPR020189--Transl_elong_IF5A_C
IPR008991--Translation_prot_SH3-like
PROSITE

PS00302--IF5A_HYPUSINE
Pfam

PF01287--eIF-5a
Gene Ontology

GO:0022626--C:cytosolic ribosome
GO:0043022--F:ribosome binding
GO:0003723--F:RNA binding
GO:0003746--F:translation elongation factor activity
GO:0045901--P:positive regulation of translational elongation
GO:0045905--P:positive regulation of translational termination
GO:0006452--P:translational frameshifting