dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006542
Uniprot Accession P19097; FAS2_YEAST; D6W3D9; Q12533;
Genbank Protein ID NP_015093.1;
Genbank Nucleotide ID NM_001184045.1;
Protein Name Fatty acid synthase subunit alpha
Protein Synonyms/Alias
Gene Name FAS2
Gene Synonyms/Alias YPL231W;P1409;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.
Phosphorylation Sites
 dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
50RVVEIGPSPTLAGMAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 18407956; 16381945; 23193290; 21177495; 21126336;
52VEIGPSPTLAGMAQRPhosphoPep 2.019060867
73ESYDAALSLHREILCcurated22817900; 25315811; 19547744
91DAKEIYYTPDPSELAcurated24961812
95IYYTPDPSELAAKEEcurated24961812
180KDLVGGKSTVQNEILPhosphoGRID 2.0;PhosphoPep 2.0;curated21126336; 19060867; 24961812; 26447709; 22817900
181DLVGGKSTVQNEILGPhosphoPep 2.0;curated19060867; 22817900; 19547744
404KKARTFDSSWNWAKQcurated24961812
443AINIMNRSNDALIKFPhosphoGRID 2.0;curated19779198; 22817900
523REKVRKLSQYVQEMAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
525KVRKLSQYVQEMALGPhosphoGRID 2.0;PhosphoPep 2.0;curated21126336; 19060867; 22369663
555TRVYKAISAQADKQDPhosphoPep 2.0;curated19060867; 25315811
564QADKQDISSSTRVEFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
567KQDISSSTRVEFEKLdbPTM 3.0;PhosphoGRID 2.017761666; 16381945; 23193290
594EIDPSQTTQLAGMDVPhosphoGRID 2.019779198
609EDALDKDSTKEVASLcurated24961812
615DSTKEVASLPNKSTIPhosphoGRID 2.021126336
827AQVILPMSPNHGTFGcurated24961812
920VVELCQKSPVMADLNcurated22369663
958SEVRKAVSIETALEHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19779198; 19060867;
Sequence
(Fasta)		MKPEVEQELA HILLTELLAY QFASPVRWIE TQDVFLKDFN TERVVEIGPS PTLAGMAQRT 60
LKNKYESYDA ALSLHREILC YSKDAKEIYY TPDPSELAAK EEPAKEEAPA PTPAASAPAP 120
AAAAPAPVAA AAPAAAAAEI ADEPVKASLL LHVLVAHKLK KSLDSIPMSK TIKDLVGGKS 180
TVQNEILGDL GKEFGTTPEK PEETPLEELA ETFQDTFSGA LGKQSSSLLS RLISSKMPGG 240
FTITVARKYL QTRWGLPSGR QDGVLLVALS NEPAARLGSE ADAKAFLDSM AQKYASIVGV 300
DLSSAASASG AAGAGAAAGA AMIDAGALEE ITKDHKVLAR QQLQVLARYL KMDLDNGERK 360
FLKEKDTVAE LQAQLDYLNA ELGEFFVNGV ATSFSRKKAR TFDSSWNWAK QSLLSLYFEI 420
IHGVLKNVDR EVVSEAINIM NRSNDALIKF MEYHISNTDE TKGENYQLVK TLGEQLIENC 480
KQVLDVDPVY KDVAKPTGPK TAIDKNGNIT YSEEPREKVR KLSQYVQEMA LGGPITKESQ 540
PTIEEDLTRV YKAISAQADK QDISSSTRVE FEKLYSDLMK FLESSKEIDP SQTTQLAGMD 600
VEDALDKDST KEVASLPNKS TISKTVSSTI PRETIPFLHL RKKTPAGDWK YDRQLSSLFL 660
DGLEKAAFNG VTFKDKYVLI TGAGKGSIGA EVLQGLLQGG AKVVVTTSRF SKQVTDYYQS 720
IYAKYGAKGS TLIVVPFNQG SKQDVEALIE FIYDTEKNGG LGWDLDAIIP FAAIPEQGIE 780
LEHIDSKSEF AHRIMLTNIL RMMGCVKKQK SARGIETRPA QVILPMSPNH GTFGGDGMYS 840
ESKLSLETLF NRWHSESWAN QLTVCGAIIG WTRGTGLMSA NNIIAEGIEK MGVRTFSQKE 900
MAFNLLGLLT PEVVELCQKS PVMADLNGGL QFVPELKEFT AKLRKELVET SEVRKAVSIE 960
TALEHKVVNG NSADAAYAQV EIQPRANIQL DFPELKPYKQ VKQIAPAELE GLLDLERVIV 1020
VTGFAEVGPW GSARTRWEME AFGEFSLEGC VEMAWIMGFI SYHNGNLKGR PYTGWVDSKT 1080
KEPVDDKDVK AKYETSILEH SGIRLIEPEL FNGYNPEKKE MIQEVIVEED LEPFEASKET 1140
AEQFKHQHGD KVDIFEIPET GEYSVKLLKG ATLYIPKALR FDRLVAGQIP TGWNAKTYGI 1200
SDDIISQVDP ITLFVLVSVV EAFIASGITD PYEMYKYVHV SEVGNCSGSG MGGVSALRGM 1260
FKDRFKDEPV QNDILQESFI NTMSAWVNML LISSSGPIKT PVGACATSVE SVDIGVETIL 1320
SGKARICIVG GYDDFQEEGS FEFGNMKATS NTLEEFEHGR TPAEMSRPAT TTRNGFMEAQ 1380
GAGIQIIMQA DLALKMGVPI YGIVAMAATA TDKIGRSVPA PGKGILTTAR EHHSSVKYAS 1440
PNLNMKYRKR QLVTREAQIK DWVENELEAL KLEAEEIPSE DQNEFLLERT REIHNEAESQ 1500
LRAAQQQWGN DFYKRDPRIA PLRGALATYG LTIDDLGVAS FHGTSTKAND KNESATINEM 1560
MKHLGRSEGN PVIGVFQKFL TGHPKGAAGA WMMNGALQIL NSGIIPGNRN ADNVDKILEQ 1620
FEYVLYPSKT LKTDGVRAVS ITSFGFGQKG GQAIVVHPDY LYGAITEDRY NEYVAKVSAR 1680
EKSAYKFFHN GMIYNKLFVS KEHAPYTDEL EEDVYLDPLA RVSKDKKSGS LTFNSKNIQS 1740
KDSYINANTI ETAKMIENMT KEKVSNGGVG VDVELITSIN VENDTFIERN FTPQEIEYCS 1800
AQPSVQSSFA GTWSAKEAVF KSLGVKSLGG GAALKDIEIV RVNKNAPAVE LHGNAKKAAE 1860
EAGVTDVKVS ISHDDLQAVA VAVSTKK 1888
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0520--NAD
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0596--Phosphopantetheine
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR008278--4-PPantetheinyl_Trfase_SF
IPR001227--Ac_transferase_dom
IPR002582--ACPS
IPR016035--Acyl_Trfase/lysoPLipase
IPR026025--FAS_alpha_yeast
IPR018201--Ketoacyl_synth_AS
IPR014031--Ketoacyl_synth_C
IPR014030--Ketoacyl_synth_N
IPR016040--NAD(P)-bd_dom
IPR004568--Ppantetheine-prot_Trfase_dom
IPR016039--Thiolase-like
PROSITE

PS00606--B_KETOACYL_SYNTHASE
PS00012--PHOSPHOPANTETHEINE
Pfam

PF01648--ACPS
PF00109--ketoacyl-synt
PF02801--Ketoacyl-synt_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005835--C:fatty acid synthase complex
GO:0004316--F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004315--F:3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004321--F:fatty-acyl-CoA synthase activity
GO:0008897--F:holo-[acyl-carrier-protein] synthase activity
GO:0000287--F:magnesium ion binding
GO:0042759--P:long-chain fatty acid biosynthetic process