dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006527
Uniprot Accession P18961; YPK2_YEAST; D6VZS6;
Genbank Protein ID NP_013822.1;
Genbank Nucleotide ID NM_001182604.1;
Protein Name Serine/threonine-protein kinase YPK2/YKR2
Protein Synonyms/Alias
Gene Name YPK2
Gene Synonyms/Alias YKR2;YMR104C;YM9718.03C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
May act as a downstream kinase in the sphingolipid-mediated signaling pathway. Plays an essential role in the proliferation of yeast cells. Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway. A substrate of TOR complex 2 (TORC2) and required for TORC2 to regulate spatial aspects of cell growth. Phosphorylation of residue Thr-501 is indispensable for function.
Phosphorylation Sites
dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20RSKEDDGSSEDENEKcurated25315811
21SKEDDGSSEDENEKScurated24603354; 23825934; 25315811
46GEKHHDGSPKNHNHEcurated25315811
63HHIRKINTNETLPSSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 20489023; 19823750;
66RKINTNETLPSSLSSPhosphoGRID 2.0;curated21177495; 19779198; 26040406; 22817900; 24961812; 25315811;
69NTNETLPSSLSSPKLcurated26447709; 20377248
70TNETLPSSLSSPKLRcurated26040406; 24961812; 20377248
72ETLPSSLSSPKLRNDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 19779198; 22817900;
73TLPSSLSSPKLRNDAPhosphoGRID 2.0;curated20489023; 25315811
81PKLRNDASFKNPSGIcurated22817900; 19547744
101KASERKASQSSTETQPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040406; 22817900; 19823750
103SERKASQSSTETQGPPhosphoPep 2.0;curated19060867; 22817900; 19823750; 25315811; 20377248
104ERKASQSSTETQGPSPhosphoPep 2.0;curated19060867; 22817900; 25315811; 20377248
105RKASQSSTETQGPSSPhosphoPep 2.0;curated19060867; 24603354; 22817900; 23825934; 20377248
107ASQSSTETQGPSSEScurated22817900
499NMKDNDKTDTFCGTPPhosphoGRID 2.0;UniProt;curated19779198; 26040289; 22817900; 23825934
501KDNDKTDTFCGTPEYdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated16055732; 17563356; 18407956; 16381945; 23193290; 20489023;
641TKEKPIDSVVDEYLSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.016055732; 17330950; 16381945; 23193290; 19779198; 19060867;
648SVVDEYLSASIQKQFPhosphoGRID 2.019779198
650VDEYLSASIQKQFGGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 19060867; 19366988;
Sequence
(Fasta)
MHSWRISKFK LGRSKEDDGS SEDENEKSWG NGLFHFHHGE KHHDGSPKNH NHEHEHHIRK 60
INTNETLPSS LSSPKLRNDA SFKNPSGIGN DNSKASERKA SQSSTETQGP SSESGLMTVK 120
VYSGKDFTLP FPITSNSTIL QKLLSSGILT SSSNDASEVA AIMRQLPRYK RVDQDSAGEG 180
LIDRAFATKF IPSSILLPGS TNSSPLLYFT IEFDNSITTI SPDMGTMEQP VFNKISTFDV 240
TRKLRFLKID VFARIPSLLL PSKNWQQEIG EQDEVLKEIL KKINTNQDIH LDSFHLPLNL 300
KIDSAAQIRL YNHHWISLER GYGKLNITVD YKPSKNKPLS IDDFDLLKVI GKGSFGKVMQ 360
VRKKDTQKIY ALKALRKAYI VSKCEVTHTL AERTVLARVD CPFIVPLKFS FQSPEKLYLV 420
LAFINGGELF YHLQHEGRFS LARSRFYIAE LLCALDSLHK LDVIYRDLKP ENILLDYQGH 480
IALCDFGLCK LNMKDNDKTD TFCGTPEYLA PEILLGQGYT KTVDWWTLGI LLYEMMTGLP 540
PYYDENVPVM YKKILQQPLL FPDGFDPAAK DLLIGLLSRD PSRRLGVNGT DEIRNHPFFK 600
DISWKKLLLK GYIPPYKPIV KSEIDTANFD QEFTKEKPID SVVDEYLSAS IQKQFGGWTY 660
IGDEQLGDSP SQGRSIS 678
Keyword

KW-0067--ATP-binding
KW-0133--Cell shape
KW-0961--Cell wall biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase
PF00433--Pkinase_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0071555--P:cell wall organization
GO:0070941--P:eisosome assembly
GO:0006468--P:protein phosphorylation
GO:0008360--P:regulation of cell shape