dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006512
Uniprot Accession P18851; GBB_YEAST; D6W2R8;
Genbank Protein ID NP_014855.3;
Genbank Nucleotide ID NM_001183631.3;
Protein Name Guanine nucleotide-binding protein subunit beta
Protein Synonyms/Alias
Gene Name STE4
Gene Synonyms/Alias YOR212W;YOR50-2;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
318FRGYEERTPTPTYMAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040406; 22369663;
320GYEERTPTPTYMAANPhosphoGRID 2.0;curated9671029; 26040406; 22369663
323ERTPTPTYMAANMEYcurated25315811
332AANMEYNTAQSPQTLPhosphoGRID 2.019779198
335MEYNTAQSPQTLKSTPhosphoGRID 2.0;curated9671029; 26040289; 25315811
338NTAQSPQTLKSTSSScurated26040289
Sequence
(Fasta)		MAAHQMDSIT YSNNVTQQYI QPQSLQDISA VEDEIQNKIE AARQESKQLH AQINKAKHKI 60
QDASLFQMAN KVTSLTKNKI NLKPNIVLKG HNNKISDFRW SRDSKRILSA SQDGFMLIWD 120
SASGLKQNAI PLDSQWVLSC AISPSSTLVA SAGLNNNCTI YRVSKENRVA QNVASIFKGH 180
TCYISDIEFT DNAHILTASG DMTCALWDIP KAKRVREYSD HLGDVLALAI PEEPNSENSS 240
NTFASCGSDG YTYIWDSRSP SAVQSFYVND SDINALRFFK DGMSIVAGSD NGAINMYDLR 300
SDCSIATFSL FRGYEERTPT PTYMAANMEY NTAQSPQTLK STSSSYLDNQ GVVSLDFSAS 360
GRLMYSCYTD IGCVVWDVLK GEIVGKLEGH GGRVTGVRSS PDGLAVCTGS WDSTMKIWSP 420
GYQ 424
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0589--Pheromone response
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
Gene Ontology

GO:0005834--C:heterotrimeric G-protein complex
GO:0005937--C:mating projection
GO:0005886--C:plasma membrane
GO:0004871--F:signal transducer activity
GO:0043577--P:chemotropism
GO:0031684--P:heterotrimeric G-protein complex cycle
GO:0001403--P:invasive growth in response to glucose limitation
GO:0000750--P:pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0010525--P:regulation of transposition, RNA-mediated