dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006500
Uniprot Accession P18759; SEC18_YEAST; D6VQ79; Q07067;
Genbank Protein ID NP_009636.3;
Genbank Nucleotide ID NM_001178428.3;
Protein Name Vesicular-fusion protein SEC18
Protein Synonyms/Alias
Gene Name SEC18
Gene Synonyms/Alias YBR080C;YBR0736;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Phosphorylation Sites
dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
15GKAAANHTPPDMTNMdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 26040406;
131RARGKAVSTVFDQDEdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812
186LGDIEPTSAVATGIEcurated24961812
218DGLVNLKSSNSLRPRPhosphoGRID 2.0;curated19779198; 22817900; 25315811
226SNSLRPRSNAVIRPDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 18407956; 16381945; 23193290; 21177495; 19060867;
296LIARKIGTMLNAKEPPhosphoGRID 2.021126336
432LQIFDIQTKKMRENNPhosphoGRID 2.0;curated19823750; 19795423; 22817900
552YVRQVRESDKSRLVScurated22817900
720VKVINELSRSCPNFNcurated22369663
735VGIKKTLTNIETARHcurated22817900; 19547744
Sequence
(Fasta)
MFKIPGFGKA AANHTPPDMT NMDTRTRHLK VSNCPNNSYA LANVAAVSPN DFPNNIYIII 60
DNLFVFTTRH SNDIPPGTIG FNGNQRTWGG WSLNQDVQAK AFDLFKYSGK QSYLGSIDID 120
ISFRARGKAV STVFDQDELA KQFVRCYESQ IFSPTQYLIM EFQGHFFDLK IRNVQAIDLG 180
DIEPTSAVAT GIETKGILTK QTQINFFKGR DGLVNLKSSN SLRPRSNAVI RPDFKFEDLG 240
VGGLDKEFTK IFRRAFASRI FPPSVIEKLG ISHVKGLLLY GPPGTGKTLI ARKIGTMLNA 300
KEPKIVNGPE ILSKYVGSSE ENIRNLFKDA EAEYRAKGEE SSLHIIIFDE LDSVFKQRGS 360
RGDGTGVGDN VVNQLLAKMD GVDQLNNILV IGMTNRKDLI DSALLRPGRF EVQVEIHLPD 420
EKGRLQIFDI QTKKMRENNM MSDDVNLAEL AALTKNFSGA EIEGLVKSAS SFAINKTVNI 480
GKGATKLNTK DIAKLKVTRE DFLNALNDVT PAFGISEEDL KTCVEGGMML YSERVNSILK 540
NGARYVRQVR ESDKSRLVSL LIHGPAGSGK TALAAEIALK SGFPFIRLIS PNELSGMSES 600
AKIAYIDNTF RDAYKSPLNI LVIDSLETLV DWVPIGPRFS NNILQMLKVA LKRKPPQDRR 660
LLIMTTTSAY SVLQQMDILS CFDNEIAVPN MTNLDELNNV MIESNFLDDA GRVKVINELS 720
RSCPNFNVGI KKTLTNIETA RHDEDPVNEL VELMTQSA 759
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport

Interpro

IPR003593--AAA+_ATPase
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase

PROSITE

PS00674--AAA

Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005795--C:Golgi stack
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0000045--P:autophagosome assembly
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0048211--P:Golgi vesicle docking
GO:0048219--P:inter-Golgi cisterna vesicle-mediated transport
GO:0016236--P:macroautophagy
GO:0035494--P:SNARE complex disassembly
GO:0042144--P:vacuole fusion, non-autophagic
GO:0048280--P:vesicle fusion with Golgi apparatus