Tag |
Content |
dbPAF ID |
dbPAF-0006500 |
Uniprot Accession |
P18759; SEC18_YEAST; D6VQ79; Q07067; |
Genbank Protein ID |
NP_009636.3; |
Genbank Nucleotide ID |
NM_001178428.3; |
Protein Name |
Vesicular-fusion protein SEC18 |
Protein Synonyms/Alias |
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Gene Name |
SEC18 |
Gene Synonyms/Alias |
YBR080C;YBR0736; |
Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
NCBI Taxa ID |
559292 |
Functional Description (View all) |
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.Functional Description
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
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Phosphorylation Sites
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dbPAF PTMs: 10 |
Sequence (Fasta) | MFKIPGFGKA AANHTPPDMT NMDTRTRHLK VSNCPNNSYA LANVAAVSPN DFPNNIYIII 60 DNLFVFTTRH SNDIPPGTIG FNGNQRTWGG WSLNQDVQAK AFDLFKYSGK QSYLGSIDID 120 ISFRARGKAV STVFDQDELA KQFVRCYESQ IFSPTQYLIM EFQGHFFDLK IRNVQAIDLG 180 DIEPTSAVAT GIETKGILTK QTQINFFKGR DGLVNLKSSN SLRPRSNAVI RPDFKFEDLG 240 VGGLDKEFTK IFRRAFASRI FPPSVIEKLG ISHVKGLLLY GPPGTGKTLI ARKIGTMLNA 300 KEPKIVNGPE ILSKYVGSSE ENIRNLFKDA EAEYRAKGEE SSLHIIIFDE LDSVFKQRGS 360 RGDGTGVGDN VVNQLLAKMD GVDQLNNILV IGMTNRKDLI DSALLRPGRF EVQVEIHLPD 420 EKGRLQIFDI QTKKMRENNM MSDDVNLAEL AALTKNFSGA EIEGLVKSAS SFAINKTVNI 480 GKGATKLNTK DIAKLKVTRE DFLNALNDVT PAFGISEEDL KTCVEGGMML YSERVNSILK 540 NGARYVRQVR ESDKSRLVSL LIHGPAGSGK TALAAEIALK SGFPFIRLIS PNELSGMSES 600 AKIAYIDNTF RDAYKSPLNI LVIDSLETLV DWVPIGPRFS NNILQMLKVA LKRKPPQDRR 660 LLIMTTTSAY SVLQQMDILS CFDNEIAVPN MTNLDELNNV MIESNFLDDA GRVKVINELS 720 RSCPNFNVGI KKTLTNIETA RHDEDPVNEL VELMTQSA
759Fasta Sequence
>P18759|SEC18|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) MFKIPGFGKAAANHTPPDMTNMDTRTRHLKVSNCPNNSYALANVAAVSPNDFPNNIYIIIDNLFVFTTRHSNDIPPGTIGFNGNQRTWGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCYESQIFSPTQYLIMEFQGHFFDLKIRNVQAIDLGDIEPTSAVATGIETKGILTKQTQINFFKGRDGLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKGLLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEESSLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLRPGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEGLVKSASSFAINKTVNIGKGATKLNTKDIAKLKVTREDFLNALNDVTPAFGISEEDLKTCVEGGMMLYSERVNSILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISPNELSGMSESAKIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPPQDRRLLIMTTTSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELSRSCPNFNVGIKKTLTNIETARHDEDPVNELVELMTQSA
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Keyword |
KW-0002--3D-structure KW-0067--ATP-binding KW-0181--Complete proteome KW-0963--Cytoplasm KW-0931--ER-Golgi transport KW-0547--Nucleotide-binding KW-0597--Phosphoprotein KW-0653--Protein transport KW-1185--Reference proteome KW-0677--Repeat KW-0813--Transport
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Interpro |
IPR003593--AAA+_ATPase IPR009010--Asp_de-COase-like_dom IPR003959--ATPase_AAA_core IPR003960--ATPase_AAA_CS IPR004201--Cdc48_dom2 IPR029067--CDC48_domain_2-like IPR003338--CDC4_N-term_subdom IPR027417--P-loop_NTPase
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PROSITE |
PS00674--AAA
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Pfam |
PF00004--AAA PF02933--CDC48_2 PF02359--CDC48_N
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Gene Ontology |
GO:0005794--C:Golgi apparatus GO:0005795--C:Golgi stack GO:0005524--F:ATP binding GO:0016887--F:ATPase activity GO:0000045--P:autophagosome assembly GO:0043001--P:Golgi to plasma membrane protein transport GO:0048211--P:Golgi vesicle docking GO:0048219--P:inter-Golgi cisterna vesicle-mediated transport GO:0016236--P:macroautophagy GO:0035494--P:SNARE complex disassembly GO:0042144--P:vacuole fusion, non-autophagic GO:0048280--P:vesicle fusion with Golgi apparatus
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