dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006413 |
| Uniprot Accession | P17967; PDI_YEAST; D6VQX3; |
| Genbank Protein ID | NP_009887.1; |
| Genbank Nucleotide ID | NM_001178688.1; |
| Protein Name | Protein disulfide-isomerase |
| Protein Synonyms/Alias | |
| Gene Name | PDI1 |
| Gene Synonyms/Alias | MFP1;TRG1;YCL043C;YCL313;YCL43C; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Protein disulfide isomerase of ER lumen required for formation of disulfide bonds in secretory and cell-surface proteins and which unscrambles non-native disulfide bonds. Forms a complex with MNL1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MKFSAGAVLS WSSLLLASSV FAQQEAVAPE DSAVVKLATD SFNEYIQSHD LVLAEFFAPW 60 CGHCKNMAPE YVKAAETLVE KNITLAQIDC TENQDLCMEH NIPGFPSLKI FKNSDVNNSI 120 DYEGPRTAEA IVQFMIKQSQ PAVAVVADLP AYLANETFVT PVIVQSGKID ADFNATFYSM 180 ANKHFNDYDF VSAENADDDF KLSIYLPSAM DEPVVYNGKK ADIADADVFE KWLQVEALPY 240 FGEIDGSVFA QYVESGLPLG YLFYNDEEEL EEYKPLFTEL AKKNRGLMNF VSIDARKFGR 300 HAGNLNMKEQ FPLFAIHDMT EDLKYGLPQL SEEAFDELSD KIVLESKAIE SLVKDFLKGD 360 ASPIVKSQEI FENQDSSVFQ LVGKNHDEIV NDPKKDVLVL YYAPWCGHCK RLAPTYQELA 420 DTYANATSDV LIAKLDHTEN DVRGVVIEGY PTIVLYPGGK KSESVVYQGS RSLDSLFDFI 480 KENGHFDVDG KALYEEAQEK AAEEADADAE LADEEDAIHD EL 523 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR005792--Prot_disulphide_isomerase |
| PROSITE | PS00014--ER_TARGET |
| Pfam | PF00085--Thioredoxin |
| Gene Ontology | GO:0005788--C:endoplasmic reticulum lumen |