dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0006404 | ||||||||
| Uniprot Accession | P17898; CPT1_YEAST; D6W152; | ||||||||
| Genbank Protein ID | NP_014269.4; | ||||||||
| Genbank Nucleotide ID | NM_001182968.3; | ||||||||
| Protein Name | Cholinephosphotransferase 1 | ||||||||
| Protein Synonyms/Alias | Aminoalcohol phosphotransferase CPT1;Diacylglycerol cholinephosphotransferase 1;Sn-1,2-diacylglycerol cholinephosphotransferase;CHOPT; | ||||||||
| Gene Name | CPT1 | ||||||||
| Gene Synonyms/Alias | YNL130C;N1218;N1867; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Catalyzes the final step in the CDP-choline route leading to phosphatidylcholin (PC). Preferentially uses CDP-monomethylethanolamine as aminoalcohol substrate. Shows highest activity toward di- and mono-unsaturated diacylglycerol species as lipid substrates. The CDP-choline pathway only contributes to net PC synthesis if exogenous choline is present. In its absence, this pathway recycles choline from PC turnover and may contribute to maintaining the proper PC species composition. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MGFFIPQSSL GNLKLYKYQS DDRSFLSNHV LRPFWRKFAT IFPLWMAPNL VTLLGFCFII 60 FNVLTTLYYD PYFDQESPRW TYFSYAIGLF LYQTFDACDG MHARRTGQQG PLGELFDHCI 120 DSINTTLSMI PVCSMTGMGY TYMTIFSQFA ILCSFYLSTW EEYHTHKLYL AEFCGPVEGI 180 IVLCISFIAV GIYGPQTIWH TKVAQFSWQD FVFDVETVHL MYAFCTGALI FNIVTAHTNV 240 VRYYESQSTK SATPSKTAEN ISKAVNGLLP FFAYFSSIFT LVLIQPSFIS LALILSIGFS 300 VAFVVGRMII AHLTMQPFPM VNFPFLIPTI QLVLYAFMVY VLDYQKGSIV SALVWMGLGL 360 TLAIHGMFIN DIIYDITTFL DIYALSIKHP KEI 394 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | |||||||||
| PROSITE | PS00379--CDP_ALCOHOL_P_TRANSF |
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| Pfam | PF01066--CDP-OH_P_transf |
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| Gene Ontology | GO:0005789--C:endoplasmic reticulum membrane |