dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006403
Uniprot Accession P17891; CLC1_YEAST; D6VUV0;
Genbank Protein ID NP_011683.3;
Genbank Nucleotide ID NM_001181296.3;
Protein Name Clathrin light chain
Protein Synonyms/Alias
Gene Name CLC1
Gene Synonyms/Alias YGR167W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi. The yeast light chain is important for cell growth. The light chain may help to properly orient the assembly/ disassembly of the clathrin coats.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
16EDQNIDFTPNDKKDDcurated24961812
41ILGDEFKTEQDDILEPhosphoGRID 2.0;curated21126336; 26040289
49EQDDILETEASPAKDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19060867; 19366988; 26040289;
52DILETEASPAKDDDEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 10069813; 21081558;
160HIDDFYDSYNKKKEQcurated22817900; 24961812
Sequence
(Fasta)		MSEKFPPLED QNIDFTPNDK KDDDTDFLKR EAEILGDEFK TEQDDILETE ASPAKDDDEI 60
RDFEEQFPDI NSANGAVSSD QNGSATVSSG NDNGEADDDF STFEGANQST ESVKEDRSEV 120
VDQWKQRRAV EIHEKDLKDE ELKKELQDEA IKHIDDFYDS YNKKKEQQLE DAAKEAEAFL 180
KKRDEFFGQD NTTWDRALQL INQDDADIIG GRDRSKLKEI LLRLKGNAKA PGA 234
Keyword

KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR000996--Clathrin_L-chain
PROSITE

PS00581--CLATHRIN_LIGHT_CHN_2
Pfam

PF01086--Clathrin_lg_ch
Gene Ontology

GO:0030132--C:clathrin coat of coated pit
GO:0030130--C:clathrin coat of trans-Golgi network vesicle
GO:0030125--C:clathrin vesicle coat
GO:0032050--F:clathrin heavy chain binding
GO:0005198--F:structural molecule activity
GO:0072583--P:clathrin-mediated endocytosis
GO:0006897--P:endocytosis
GO:0006886--P:intracellular protein transport
GO:0045807--P:positive regulation of endocytosis