| Tag |
Content |
| dbPAF ID |
dbPAF-0006383 |
| Uniprot Accession |
P17709; HXKG_YEAST; D6VQX5;
|
| Genbank Protein ID |
NP_009890.1;
|
| Genbank Nucleotide ID |
NM_001178685.1;
|
| Protein Name |
Glucokinase-1 |
| Protein Synonyms/Alias |
Glucose kinase 1;GLK-1; |
| Gene Name |
GLK1 |
| Gene Synonyms/Alias |
HOR3;YCL040W;YCL312;YCL40W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake.Functional Description
Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSFDDLHKAT ERAVIQAVDQ ICDDFEVTPE KLDELTAYFI EQMEKGLAPP KEGHTLASDK 60
GLPMIPAFVT GSPNGTERGV LLAADLGGTN FRICSVNLHG DHTFSMEQMK SKIPDDLLDD 120
ENVTSDDLFG FLARRTLAFM KKYHPDELAK GKDAKPMKLG FTFSYPVDQT SLNSGTLIRW 180
TKGFRIADTV GKDVVQLYQE QLSAQGMPMI KVVALTNDTV GTYLSHCYTS DNTDSMTSGE 240
ISEPVIGCIF GTGTNGCYME EINKITKLPQ ELRDKLIKEG KTHMIINVEW GSFDNELKHL 300
PTTKYDVVID QKLSTNPGFH LFEKRVSGMF LGEVLRNILV DLHSQGLLLQ QYRSKEQLPR 360
HLTTPFQLSS EVLSHIEIDD STGLRETELS LLQSLRLPTT PTERVQIQKL VRAISRRSAY 420
LAAVPLAAIL IKTNALNKRY HGEVEIGCDG SVVEYYPGFR SMLRHALALS PLGAEGERKV 480
HLKIAKDGSG VGAALCALVA
501Fasta Sequence
>P17709|GLK1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSFDDLHKATERAVIQAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTERGVLLAADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDELAKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCDGSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA
|
| Keyword |
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0324--Glycolysis
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR001312--Hexokinase
IPR019807--Hexokinase_BS
IPR022673--Hexokinase_C
IPR022672--Hexokinase_N
|
| PROSITE |
PS00378--HEXOKINASE_1
PS51748--HEXOKINASE_2
|
| Pfam |
PF00349--Hexokinase_1
PF03727--Hexokinase_2
|
| Gene Ontology |
GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0008865--F:fructokinase activity
GO:0004340--F:glucokinase activity
GO:0005536--F:glucose binding
GO:0019158--F:mannokinase activity
GO:0001678--P:cellular glucose homeostasis
GO:0051156--P:glucose 6-phosphate metabolic process
GO:0046323--P:glucose import
GO:0006006--P:glucose metabolic process
GO:0006096--P:glycolytic process
GO:0006013--P:mannose metabolic process
|
