dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006378
Uniprot Accession P17695; GLRX2_YEAST; D6VTD4; Q6B234;
Genbank Protein ID NP_010801.1;
Genbank Nucleotide ID NM_001180821.1;
Protein Name Glutaredoxin-2, mitochondrial
Protein Synonyms/Alias Glutathione-dependent oxidoreductase 2;Thioltransferase;
Gene Name GRX2
Gene Synonyms/Alias TTR;TTR1;YDR513W;D9719.17;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the glutathione system which performs several activities such as glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. GRX2 is more active as an oxidoreductase than GRX1.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
31IIAKRFLSTPKMVSQcurated22817900; 19823750
37LSTPKMVSQETVAHVdbPTM 3.0;SysPTM 2.0;UniProt18407956; 16381945; 23193290; 19366988
69PYCKATLSTLFQELNcurated26040406; 24961812
91VLELDEMSNGSEIQDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19823750; 19779198; 19795423;
94LDEMSNGSEIQDALEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19823750; 19795423; 21081558;
123GKHIGGNSDLETLKKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
127GGNSDLETLKKNGKLPhosphoPep 2.019060867
Sequence
(Fasta)		METNFSFDSN LIVIIIITLF ATRIIAKRFL STPKMVSQET VAHVKDLIGQ KEVFVAAKTY 60
CPYCKATLST LFQELNVPKS KALVLELDEM SNGSEIQDAL EEISGQKTVP NVYINGKHIG 120
GNSDLETLKK NGKLAEILKP VFQ 144
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0249--Electron transport
KW-0318--Glutathionylation
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-0676--Redox-active center
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR011767--GLR_AS
IPR002109--Glutaredoxin
IPR011899--Glutaredoxin_euk/vir
IPR014025--Glutaredoxin_subgr
IPR012336--Thioredoxin-like_fold
PROSITE

PS00195--GLUTAREDOXIN_1
PS51354--GLUTAREDOXIN_2
Pfam

PF00462--Glutaredoxin
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0015036--F:disulfide oxidoreductase activity
GO:0009055--F:electron carrier activity
GO:0004602--F:glutathione peroxidase activity
GO:0004364--F:glutathione transferase activity
GO:0015035--F:protein disulfide oxidoreductase activity
GO:0045454--P:cell redox homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0006749--P:glutathione metabolic process