dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006369
Uniprot Accession P17649; GABAT_YEAST; A5H0J7; D6VUF4;
Genbank Protein ID NP_011533.3;
Genbank Nucleotide ID NM_001181148.3;
Protein Name 4-aminobutyrate aminotransferase
Protein Synonyms/Alias GABA aminotransferase;GABA-AT;Gamma-amino-N-butyrate transaminase;GABA transaminase;
Gene Name UGA1
Gene Synonyms/Alias YGR019W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL).
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
21KPTVKTESIPGPESQcurated22369663
90ALIKAAQSPEMIRALdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
451VRLRPSLTFEEKHADcurated19547744
Sequence
(Fasta)		MSICEQYYPE EPTKPTVKTE SIPGPESQKQ LKELGEVFDT RPAYFLADYE KSLGNYITDV 60
DGNTYLDLYA QISSIALGYN NPALIKAAQS PEMIRALVDR PALGNFPSKD LDKILKQILK 120
SAPKGQDHVW SGLSGADANE LAFKAAFIYY RAKQRGYDAD FSEKENLSVM DNDAPGAPHL 180
AVLSFKRAFH GRLFASGSTT CSKPIHKLDF PAFHWPHAEY PSYQYPLDEN SDANRKEDDH 240
CLAIVEELIK TWSIPVAALI IEPIQSEGGD NHASKYFLQK LRDITLKYNV VYIIDEVQTG 300
VGATGKLWCH EYADIQPPVD LVTFSKKFQS AGYFFHDPKF IPNKPYRQFN TWCGEPARMI 360
IAGAIGQEIS DKKLTEQCSR VGDYLFKKLE GLQKKYPENF QNLRGKGRGT FIAWDLPTGE 420
KRDLLLKKLK LNGCNVGGCA VHAVRLRPSL TFEEKHADIF IEALAKSVNE L 472
Keyword

KW-0032--Aminotransferase
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR004631--4NH2But_aminotransferase_euk
IPR005814--Aminotrans_3
IPR015424--PyrdxlP-dep_Trfase
IPR015421--PyrdxlP-dep_Trfase_major_sub1
IPR015422--PyrdxlP-dep_Trfase_major_sub2
PROSITE

PS00600--AA_TRANSFER_CLASS_3
Pfam

PF00202--Aminotran_3
Gene Ontology

GO:0005829--C:cytosol
GO:0003867--F:4-aminobutyrate transaminase activity
GO:0042802--F:identical protein binding
GO:0030170--F:pyridoxal phosphate binding
GO:0009058--P:biosynthetic process
GO:0009450--P:gamma-aminobutyric acid catabolic process