dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006367
Uniprot Accession P17629; HPR1_YEAST; D6VSC1; Q03918;
Genbank Protein ID NP_010422.1;
Genbank Nucleotide ID NM_001180445.1;
Protein Name THO complex subunit HPR1
Protein Synonyms/Alias Hyperrecombination protein 1;
Gene Name HPR1
Gene Synonyms/Alias YDR138W;YD9302.14;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
165EPVSLGESNLISYKQcurated25521595
170GESNLISYKQPLYEKcurated25521595
227SNFNRSASISALQESdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900; 25315811;
229FNRSASISALQESDNcurated25315811
234SISALQESDNEWNRSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19779198; 19060867;
619KVEALDDSFKEKLLYdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
673IKSQRINSASQTEGDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20702584; 19779198; 19060867;
675SQRINSASQTEGDELdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20190278; 19823750;
694TQPKGEISEENTKIKcurated25315811
707IKSSEVSSQDPDSGVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MSNTEELIQN SIGFLQKTFK ALPVSFDSIR HEPLPSSMLH ASVLNFEWEP LEKNISAIHD 60
RDSLIDIILK RFIIDSMTNA IEDEEENNLE KGLLNSCIGL DFVYNSRFNR SNPASWGNTF 120
FELFSTIIDL LNSPSTFLKF WPYAESRIEW FKMNTSVEPV SLGESNLISY KQPLYEKLRH 180
WNDILAKLEN NDILNTVKHY NMKYKLENFL SELLPINEES NFNRSASISA LQESDNEWNR 240
SARERESNRS SDVIFAADYN FVFYHLIICP IEFAFSDLEY KNDVDRSLSP LLDAILEIEE 300
NFYSKIKMNN RTRYSLEEAL NTEYYANYDV MTPKLPVYMK HSNAMKMDRN EFWANLQNIK 360
ESDDYTLRPT IMDISLSNTT CLYKQLTQED DDYYRKQFIL QLCFTTNLIR NLISSDETRN 420
FYKSCYLREN PLSDIDFENL DEVNKKRGLN LCSYICDNRV LKFYKIKDPD FYRVIRKLMS 480
SDEKFTTAKI DGFKEFQNFR ISKEKIPPPA FDETFKKFTF IKMGNKLINN VWKIPTGLDK 540
IEQEVKKPEG VYEAAQAKWE SKISSETSGG EAKDEIIRQW QTLRFLRSRY LFDFDKVNEK 600
TGVDGLFEEP RKVEALDDSF KEKLLYKINQ EHRKKLQDAR EYKIGKERKK RALEEEASFP 660
EREQKIKSQR INSASQTEGD ELKSEQTQPK GEISEENTKI KSSEVSSQDP DSGVAGEFAP 720
QNTTAQLENP KTEDNNAATS NISNGSSTQD MK 753
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR021861--THO_THOC1
PROSITE
Pfam

PF11957--efThoc1
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0000446--C:nucleoplasmic THO complex
GO:0000445--C:THO complex part of transcription export complex
GO:0003676--F:nucleic acid binding
GO:0032947--F:protein complex scaffold
GO:0006310--P:DNA recombination
GO:0031124--P:mRNA 3'-end processing
GO:0006406--P:mRNA export from nucleus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair