dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006358
Uniprot Accession P17555; CAP_YEAST; D6W144;
Genbank Protein ID NP_014261.1;
Genbank Nucleotide ID NM_001182976.1;
Protein Name Adenylyl cyclase-associated protein
Protein Synonyms/Alias
Gene Name SRV2
Gene Synonyms/Alias CAP1;YNL138W;N1210;N1838;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
256FADAMAQSTKNTGATcurated25315811
267TGATSSPSPASATAAPhosphoPep 2.019060867
342KNPELRQSSTVSSTGPhosphoGRID 2.0;curated21126336; 22817900; 19823750; 24961812; 20377248
343NPELRQSSTVSSTGScurated22817900; 24961812; 25315811; 20377248
344PELRQSSTVSSTGSKcurated22817900; 20377248
346LRQSSTVSSTGSKSGcurated24961812; 20377248
347RQSSTVSSTGSKSGPcurated19823750; 25315811; 20377248
350STVSSTGSKSGPPPRcurated24961812; 25315811; 20377248
454FGIQVNHSLPQISIDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040406; 24961812
459NHSLPQISIDKSDGGcurated26040406
469KSDGGNIYLSKESLNcurated26040406
471DGGNIYLSKESLNTEcurated26040406; 25315811
Sequence
(Fasta)		MPDSKYTMQG YNLVKLLKRL EEATARLEDV TIYQEGYIQN KLEASKNNKP SDSGADANTT 60
NEPSAENAPE VEQDPKCITA FQSYIGENID PLVELSGKID TVVLDALQLL KGGFQSQLTF 120
LRAAVRSRKP DYSSQTFADS LRPINENIIK LGQLKESNRQ SKYFAYLSAL SEGAPLFSWV 180
AVDTPVSMVT DFKDAAQFWT NRILKEYRES DPNAVEWVKK FLASFDNLKA YIKEYHTTGV 240
SWKKDGMDFA DAMAQSTKNT GATSSPSPAS ATAAPAPPPP PPAPPASVFE ISNDTPATSS 300
DANKGGIGAV FAELNQGENI TKGLKKVDKS QQTHKNPELR QSSTVSSTGS KSGPPPRPKK 360
PSTLKTKRPP RKELVGNKWF IENYENETES LVIDANKDES IFIGKCSQVL VQIKGKVNAI 420
SLSETESCSV VLDSSISGMD VIKSNKFGIQ VNHSLPQISI DKSDGGNIYL SKESLNTEIY 480
TSCSTAINVN LPIGEDDDYV EFPIPEQMKH SFADGKFKSA VFEHAG 527
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR001837--Adenylate_cyclase-assoc_CAP
IPR013912--Adenylate_cyclase-assoc_CAP_C
IPR013992--Adenylate_cyclase-assoc_CAP_N
IPR017901--C-CAP_CF_C-like
IPR016098--CAP/MinC_C
IPR028417--CAP_CS_C
IPR018106--CAP_CS_N
IPR028419--CAP_fungal_type
IPR006599--CARP_motif
PROSITE

PS51329--C_CAP_COFACTOR_C
PS01088--CAP_1
PS01089--CAP_2
Pfam

PF08603--CAP_C
PF01213--CAP_N
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0003779--F:actin binding
GO:0008179--F:adenylate cyclase binding
GO:0042802--F:identical protein binding
GO:0007015--P:actin filament organization
GO:0051014--P:actin filament severing
GO:0000902--P:cell morphogenesis
GO:0007265--P:Ras protein signal transduction