dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006340
Uniprot Accession P17442; PHO81_YEAST; D6VV13; Q06887;
Genbank Protein ID NP_011749.3;
Genbank Nucleotide ID NM_001181362.3;
Protein Name Phosphate system positive regulatory protein PHO81
Protein Synonyms/Alias CDK inhibitor PHO81;
Gene Name PHO81
Gene Synonyms/Alias YGR233C;G8567;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Inhibits the kinase activity of the cyclin-CDKs PHO80-PHO85 and PCL7-PHO85 under low-phosphate conditions.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
42AIPTLKASSDLDLHLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
43IPTLKASSDLDLHLTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 24961812
213RADIQSSTFTNDDDDcurated25315811
215DIQSSTFTNDDDDDNPhosphoGRID 2.0;curated20489023; 25315811
224DDDDDNNTSNNNKHNcurated25315811
348LFLLLVASPLDDNSLPhosphoGRID 2.015127225
461PIDSDSKTPLVLAITPhosphoGRID 2.015127225
487TIGGANASPIEKPILdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 15127225; 19366988;
542ADNAKNKSSQHLCQPdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 25315811
543DNAKNKSSQHLCQPLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.018407956; 16381945; 23193290; 19779198; 19366988
627IEDDNGHSPLFYALWdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
661APLNEINSQSSTQRLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
664NEINSQSSTQRLNTIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
665EINSQSSTQRLNTIDdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25315811
670SSTQRLNTIDLTPNDcurated26040406
674RLNTIDLTPNDDKFDPhosphoGRID 2.0;curated20489023; 25315811
687FDLDIQDSIPDFALPPhosphoGRID 2.020489023
737DNGIIMSSSPGRITLPhosphoGRID 2.020489023
738NGIIMSSSPGRITLSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
956DFGKIDGSFDEVTLKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20190278; 19366988
Sequence
(Fasta)		MKFGKYLEAR QLELAEYNSH FIDYKALKKL IKQLAIPTLK ASSDLDLHLT LDDIDEKIIH 60
QRLQENKAAF FFKLERELEK VNGYYLARES DLRIKFNILH SKYKDYKING KLNSNQATSF 120
KNLYAAFKKF QKDLRNLEQY VELNKTGFSK ALKKWDKRSQ SHDKDFYLAT VVSIQPIFTR 180
DGPLKLNDET LHILLELNDI DNNNRRADIQ SSTFTNDDDD DNNTSNNNKH NNNNNNNNNN 240
NNNNNNNNIL HNNYELTTSK ISENQLEHLF QASSSSLDME MEIENWYKEI LNIATVKDVQ 300
RKHALLRNFR ETKIFTYLLQ NSSESFHKNV FSLLKECLTT LFLLLVASPL DDNSLHIFYK 360
SNQDHIDLSY CDEDDQVFSR KNVFHEAASC PEKSRLFILD EALTTSKLSK ETVQKLLNAQ 420
DIHSRVPLHY AAELGKLEFV HSLLITNLLE DVDPIDSDSK TPLVLAITNN HIDVVRDLLT 480
IGGANASPIE KPILDYSKNV ISSTKVQFDP LNVACKFNNH DAAKLLLEIR SKQNADNAKN 540
KSSQHLCQPL FKKNSTGLCT LHIVAKIGGD PQLIQLLIRY GADPNEIDGF NKWTPIFYAV 600
RSGHSEVITE LLKHNARLDI EDDNGHSPLF YALWESHVDV LNALLQRPLN LPSAPLNEIN 660
SQSSTQRLNT IDLTPNDDKF DLDIQDSIPD FALPPPIIPL RKYGHNFLEK KIFIKLKLRP 720
GLESIKLTQD NGIIMSSSPG RITLSSNLPE IIPRNVILPV RSGEINNFCK DISETNDEED 780
DDEISEDHDD GEIIFQVDSI DDFSMDFEIF PSFGTRIIAK TTAMPFLFKK VAINSIATMN 840
LPLFDTRLNN IGSLTLDYQI IFPYPGNPLK IINYEPYWKS TGSDLMTSSK DGNFVTSSSL 900
NGSFISVLVC ALNDETIVAA PKPYVEFKGT KILLNDLTKE QLEKVVDYDF GKIDGSFDEV 960
TLKQYLSSRV VPLRSLLEVI PGSAQLVIRV YFPTDKEIDT IPIKISPFIN INQFIDKLLL 1020
IIFEHERFLR HSGSGSMRQI VFSSCNWEAC SILNWKQPNF PVLLQMKNLL RDSTTGKFVG 1080
DTPNCLKELA VNPQKMSYLN TELINIHTMV QFAMNNNLLG VTLPYEVLKI CPSLARIIKQ 1140
NGLLLIASVG ENDQIPADGG YSGIYYACEL LFENNIDM 1179
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR030395--GP_PDE_dom
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR004331--SPX_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51704--GP_PDE
PS51382--SPX
Pfam

PF12796--Ank_2
PF03105--SPX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004861--F:cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0008081--F:phosphoric diester hydrolase activity
GO:0006629--P:lipid metabolic process
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0006796--P:phosphate-containing compound metabolic process