dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006333
Uniprot Accession P17423; KHSE_YEAST; D3DKX2;
Genbank Protein ID NP_011890.1;
Genbank Nucleotide ID NM_001179155.1;
Protein Name Homoserine kinase
Protein Synonyms/Alias
Gene Name THR1
Gene Synonyms/Alias YHR025W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
167GSFLRDLTPQEVERRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MVRAFKIKVP ASSANIGPGY DVLGVGLSLF LELDVTIDSS QAQETNDDPN NCKLSYTKES 60
EGYSTVPLRS DANLITRTAL YVLRCNNIRN FPSGTKVHVS NPIPLGRGLG SSGAAVVAGV 120
ILGNEVAQLG FSKQRMLDYC LMIERHPDNI TAAMMGGFCG SFLRDLTPQE VERREIPLAE 180
VLPEPSGGED TGLVPPLPPT DIGRHVKYQW NPAIKCIAII PQFELSTADS RGVLPKAYPT 240
QDLVFNLQRL AVLTTALTMD PPNADLIYPA MQDRVHQPYR KTLIPGLTEI LSCVTPSTYP 300
GLLGICLSGA GPTILALATE NFEEISQEII NRFAKNGIKC SWKLLEPAYD GASVEQQ 358
Keyword

KW-0028--Amino-acid biosynthesis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0791--Threonine biosynthesis
KW-0808--Transferase
Interpro

IPR013750--GHMP_kinase_C_dom
IPR006204--GHMP_kinase_N_dom
IPR006203--GHMP_knse_ATP-bd_CS
IPR000870--Homoserine_kinase
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
PROSITE

PS00627--GHMP_KINASES_ATP
Pfam

PF00288--GHMP_kinases_N
Gene Ontology

GO:0005524--F:ATP binding
GO:0004413--F:homoserine kinase activity
GO:0009092--P:homoserine metabolic process
GO:0006549--P:isoleucine metabolic process
GO:0006555--P:methionine metabolic process
GO:0009088--P:threonine biosynthetic process