dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006316
Uniprot Accession P17214; EST1_YEAST; D6VYN3; Q05997;
Genbank Protein ID NP_013334.1;
Genbank Nucleotide ID NM_001182120.1;
Protein Name Telomere elongation protein EST1
Protein Synonyms/Alias Ever shorter telomeres protein 1;
Gene Name EST1
Gene Synonyms/Alias YLR233C;L8083.15;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Directly involved in telomere replication. Associates with telomerase and during its interaction with CDC13, telomerase activity is promoted.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
285NLKDFILTPDFPERRPhosphoGRID 2.021126336
548ECVLRIRSIIFSGMKPhosphoGRID 2.021126336
644VRRTKKLSPLPEKDGcurated22817900
Sequence
(Fasta)		MDNEEVNEEC MRLFFKNARA HLDKHLTSRL TCDENAYITF RCFLDGIHRK STRFLEELLL 60
KQENMYHNNN YERINDSVIP LVLKLLWLQI HEPTLQWFEH WFHDIMRLSN RRKFRVFRIF 120
QKKMIQFFKI THRYYYDIIE HLCAKYDMNS VISNALFAKL NLMQYTDGLS THEKIILNTS 180
NPLTFSIVIS LQRCVINLGS THFYKTLLNK PSNKPKSVEG FEKSIRYLNI ASLYLPAVGD 240
TYFQRAKIYL ITGKFSLYFF ELVRGALVRI PSKCALNNLK DFILTPDFPE RRRLMKKLAI 300
LVSKDLKGEK SFFEGQIVLQ FLSIVEHTLV PQSWNASRAS NCWLLKEHLQ MAALKYHSGN 360
INVILENLAA TMGSFDLMFT TRKSKEQKNK LKYADLSERQ VFFLDLSFDF IANIIDVVIK 420
PSWQKNMEDF RYLAIIRLLM CWIKSYRSIL QYTHRHRKFC TSFALLLNDL INSPLNCSGN 480
IYSHRPKRSY LFREDIIFRE FSCINFALTD FNDDYVYDSP DMINNIIGCP TLTKVLSPKE 540
ECVLRIRSII FSGMKFLEKN DTGVIWNASK YKFDLISPNI KIKRQIALSE ISSKINVKTQ 600
QERVVSSRKV EAKRDEQQRK RAGKIAVTEL EKQFANVRRT KKLSPLPEKD GVSSELVKHA 660
ASRGRKTITG PLSSDFLSYP DEAIDADEDI TVQVPDTPT
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
Interpro

IPR018834--DNA/RNA-bd_Est1-type
IPR019458--EST1
IPR011990--TPR-like_helical_dom
PROSITE
Pfam

PF10374--EST1
PF10373--EST1_DNA_bind
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005697--C:telomerase holoenzyme complex
GO:0003723--F:RNA binding
GO:0003697--F:single-stranded DNA binding
GO:0042162--F:telomeric DNA binding
GO:0071919--P:G-quadruplex DNA formation
GO:0000723--P:telomere maintenance
GO:0007004--P:telomere maintenance via telomerase