dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006301
Uniprot Accession P17121; SAC7_YEAST; D6VT23; Q04163;
Genbank Protein ID NP_010677.1;
Genbank Nucleotide ID NM_001180697.1;
Protein Name GTPase-activating protein SAC7
Protein Synonyms/Alias
Gene Name SAC7
Gene Synonyms/Alias YDR389W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 GTPase-activating protein for RHO1. Must be involved in the normal assembly or function or both of actin. Plays an essential role only at low temperatures.
Phosphorylation Sites
 dbPAF PTMs: 42 (View all)
PositionPeptidesSourceReferences ( PMIDs )
10NNTLKQGSKIENVSPcurated22817900
16GSKIENVSPSKGHVPPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 20702584; 19779198; 19060867; 26040289; 22817900;
35QFINNPKSMSSENITPhosphoGRID 2.0;PhosphoPep 2.0;curated21126336; 20702584; 19779198; 19060867; 22369663; 22817900;
37INNPKSMSSENITVPdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20702584; 19779198; 19060867;
38NNPKSMSSENITVPRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 19060867; 19366988; 22817900;
42SMSSENITVPRSPTSPhosphoGRID 2.0;curated19684113; 22817900; 20377248
46ENITVPRSPTSLSRNdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 16381945; 23193290; 19779198; 19060867;
48ITVPRSPTSLSRNAQPhosphoPep 2.0;curated19060867; 22817900
49TVPRSPTSLSRNAQPPhosphoPep 2.019060867
51PRSPTSLSRNAQPTTPhosphoPep 2.019060867
69PPLSSRPYSYNTPTKcurated26040289
70PLSSRPYSYNTPTKDcurated26040289; 25704821; 24961812; 20377248
71LSSRPYSYNTPTKDRcurated20377248
80TPTKDRKSFSKSAKQPhosphoGRID 2.0;curated21177495; 22817900
82TKDRKSFSKSAKQNNPhosphoGRID 2.0;curated21177495; 22817900
84DRKSFSKSAKQNNNNPhosphoGRID 2.0;curated21177495; 22817900
96NNNNNANSGTSPHAEPhosphoPep 2.019060867
98NNNANSGTSPHAEFKPhosphoPep 2.0;curated19060867; 26040289; 22817900
99NNANSGTSPHAEFKNdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 21177495; 19684113;
107PHAEFKNYRDMFLSNPhosphoPep 2.019060867
Sequence
(Fasta)		MPNNTLKQGS KIENVSPSKG HVPSFWKQFI NNPKSMSSEN ITVPRSPTSL SRNAQPTTLK 60
RPPLSSRPYS YNTPTKDRKS FSKSAKQNNN NNNANSGTSP HAEFKNYRDM FLSNRNGFTG 120
RVFGVTLAES LSVASAEVIV QSELVSFGRI PIVVAKCGAY LKANGLETSG IFRIAGNGKR 180
VKALQYIFSS PPDYGTKFND WETYTVHDVA SLLRRYLNNL AEPLIPLSLY EQFRNPLRSR 240
PRILRHMLTH EVSHPNANKT NNVTVKSSRQ NYNDDGANDG DIEKEDAKDD EEKRRRKIRH 300
KRRLTRDIRA AIKEYEELFV TLSNDTKQLT IYLLDLLSLF ARQSQFNLMS GRNLAAIFQP 360
SILSHPQHDM DPKEYELSRL VVEFLIEYSY KLLPHLLKLA KREQQERLST ENKKNNGDKQ 420
KTDPIEIPKI TSSDSPPIVS SNKNPPAIDN NNKLDHTTLS PISTSIPENS SDLQTSKMLK 480
PPKQRRPHSK SFGSTPVPPD VIASNKRRTS LFPWLHKPGI LSDTGDNGDL TATEAEGDDY 540
EEENVDPYGQ SPSSVHSGSL PKQHYLPIPR MNRSLSGNST NSSFNTRPIS MILTSGNDNS 600
ADQLELLSNT HSNNERSNAL PLTEDDGDER NSRSRKRESW FQRLTSRSGS ANRA 655
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
PROSITE

PS50238--RHOGAP
Pfam

PF00620--RhoGAP
Gene Ontology

GO:0005938--C:cell cortex
GO:0005856--C:cytoskeleton
GO:0005096--F:GTPase activator activity
GO:0090038--P:negative regulation of protein kinase C signaling
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0043547--P:positive regulation of GTPase activity
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0060237--P:regulation of fungal-type cell wall organization
GO:0007165--P:signal transduction