dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006254 |
| Uniprot Accession | P16892; FUS3_YEAST; D6VPY4; |
| Genbank Protein ID | NP_009537.1; |
| Genbank Nucleotide ID | NM_001178256.1; |
| Protein Name | Mitogen-activated protein kinase FUS3 |
| Protein Synonyms/Alias | |
| Gene Name | FUS3 |
| Gene Synonyms/Alias | DAC2;YBL016W;YBL03.21;YBL0303; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Together with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways. Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes. Non-activated FUS3 has a repressive effect on STE12 transcriptional activity. KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling. FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12. |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MPKRIVYNIS SDFQLKSLLG EGAYGVVCSA THKPTGEIVA IKKIEPFDKP LFALRTLREI 60 KILKHFKHEN IITIFNIQRP DSFENFNEVY IIQELMQTDL HRVISTQMLS DDHIQYFIYQ 120 TLRAVKVLHG SNVIHRDLKP SNLLINSNCD LKVCDFGLAR IIDESAADNS EPTGQQSGMT 180 EYVATRWYRA PEVMLTSAKY SRAMDVWSCG CILAELFLRR PIFPGRDYRH QLLLIFGIIG 240 TPHSDNDLRC IESPRAREYI KSLPMYPAAP LEKMFPRVNP KGIDLLQRML VFDPAKRITA 300 KEALEHPYLQ TYHDPNDEPE GEPIPPSFFE FDHYKEALTT KDLKKLIWNE IFS 354 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR011009--Kinase-like_dom |
| PROSITE | PS01351--MAPK |
| Pfam | PF00069--Pkinase |
| Gene Ontology | GO:0005737--C:cytoplasm |