dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006241
Uniprot Accession P16664; RGP1_YEAST; D6VSC0; Q03915;
Genbank Protein ID NP_010421.1;
Genbank Nucleotide ID NM_001180444.1;
Protein Name Guanine nucleotide exchange factor subunit RGP1
Protein Synonyms/Alias Reduced growth phenotype protein 1;Rgp1p;
Gene Name RGP1
Gene Synonyms/Alias YDR137W;YD9302.13;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
229NERTLMISNDTSIKTcurated22817900
232TLMISNDTSIKTLPLcurated22817900
351RLFTRKVSTASAVSFdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19684113; 19779198;
352LFTRKVSTASAVSFGPhosphoPep 2.0;curated19060867; 22817900
354TRKVSTASAVSFGRRdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19684113; 19779198;
357VSTASAVSFGRRKSSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19684113; 19779198;
363VSFGRRKSSIIDIDSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21126336;
364SFGRRKSSIIDIDSPdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 20702584;
370SSIIDIDSPLEDNEFPhosphoGRID 2.0;UniProt19779198
417QFGKDEDSSDPEPNDcurated25315811; 22817900
418FGKDEDSSDPEPNDScurated25315811; 22817900
450AVTKRRKSYSVRDNIPhosphoGRID 2.0;curated19823750; 19795423; 22369663; 22817900; 25521595; 24961812
451VTKRRKSYSVRDNIScurated20377248
452TKRRKSYSVRDNISNcurated20377248
458YSVRDNISNLEQKMWcurated25315811
498QINRNNETMAKVSLScurated22817900
Sequence
(Fasta)		MRAHRIDTFL IRENIKLEII HESNSYFGGE HISIAFRFKH LGSQHELFNY KEKLLTVDKA 60
VEEKLEQQAK VQDDGEGTME NQTWSLKSLL GAFKRTGEPE ESVDVDNMKM LNESKMLREK 120
IQKQMYFHQP VTLISGYVQI SGVFQYDSEV ISESKFKQDE VKMVGLDIVP GHTTNSVLAL 180
EDGEHFKGKR NLTNYLNSDY TNVTNGLLFS ESGSRGRTGT YNERTLMISN DTSIKTLPLL 240
LIPQTLLFSE ISLEPGEVRT FYFKSTKLPK DICPSYSSSK VASINYTLEV GADVLSDDNI 300
EKFSNRVPIT IAPYISSNAE QYTSRLDKPA IILKTGNIKE LKPRLFTRKV STASAVSFGR 360
RKSSIIDIDS PLEDNEFVKR VKKNFIELVE SNQNVSRDID ELIDLQMGVQ FGKDEDSSDP 420
EPNDSHFSNE MVTSAESSLR SDAVTKRRKS YSVRDNISNL EQKMWNDCSL VKSDENSNLL 480
PQLINLQNAY QINRNNETMA KVSLSAPFYK TTDDINLVIE LDPITTPLLK VTSLTVSLES 540
FEIINPKYKT EGKGIGSKPK GNSVYEKHFI CFDECKSVSV KLLPPRSPTN QITGQFKTDV 600
FQHKWMIGLK FVIIAKTESI TLDQFYEDKK GILFHSKENL EGEEFTCYVP IPILCTSEDF 660
MGW 664
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0344--Guanine-nucleotide releasing factor
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR014848--Rgp1
PROSITE
Pfam

PF08737--Rgp1
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0032045--C:guanyl-nucleotide exchange factor complex
GO:0034066--C:RIC1-RGP1 guanyl-nucleotide exchange factor complex
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043547--P:positive regulation of GTPase activity
GO:0042147--P:retrograde transport, endosome to Golgi