Functional Description
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Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.Functional Description
Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex. |
| Gene Ontology |
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0008023--C:transcription elongation factor complex
GO:0017053--C:transcriptional repressor complex
GO:0042393--F:histone binding
GO:0042826--F:histone deacetylase binding
GO:0036033--F:mediator complex binding
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0043486--P:histone exchange
GO:0035955--P:negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
GO:0001198--P:negative regulation of mating-type specific transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0000433--P:negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0016584--P:nucleosome positioning
GO:2000531--P:regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
GO:2000217--P:regulation of invasive growth in response to glucose limitation
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006351--P:transcription, DNA-templated
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